Effect of Glomerular Capillary Wall Alteration on the Distribution of Immune Complex

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An investigation was performed to show whether an alteration of permselectivity of glomerular capillary wall (GCW) per se may influence the distribution of immune complex (IC) in the development of experimental ic nephritis. Apoferritin was used to induce IC nephritis in mice. To alter the permselectivity of GCW, daunomycin was injected to mice prior to the immunization with apoferritin. The results were compared between the animals in which apoferritin alone was given and those in which daunomycin and apoferritin were administered. In the former animals, the IgG and C_3 distribution was confined to mesangial area, thile the latter showed IgG and C_3 not only in mesangial area but also along the capillary wall.As expected, daunomycin administration induced increased urinary IgG and albumin excretion reflecting the enhanced macromolecular permselectivity in GCW. However, an alteration of antibody production or that of affinity of IC was not noted, which may be a factor other than the macromolecular permelectivity of GCW per se, responsible for the alteration of IC distribution. The findings suggest that charge of GCW per se can induce the althration of IC distribution in glomeruli, and may provide a clue for the future development of effective therapy for glomerulonephritis.