Experimental study on intestinal adaptation after entestinal surgery Special rifference to gut hormonl and evoked potentiel dtterence.

肠手术后肠道适应的实验研究，特别涉及肠道激素和诱发电位差异。

• 批准号: 62570588
• 负责人: SASAKI Iwao
• 金额: $ 1.28万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570588/
• 关键词: enterefuoagun; intertinal evoked potertial difference; glycentin; CIPR; intestunal adoptation; gvt-GLI; intest,nal adaptation; intestinal adaptatcin; ileojejunal transposition; antecozlucagon; ayptocell production ratis (C C P R); 糖誘発〓位

The effect of ileojcjunal transposition (IJT) or the intestinal adaptation after surgery was investigated in both dogs anf rats. Hyperenteroglu cognomina was observed 5,12 weeks and 6 months after operation in mongrel dogs. G.l filhation pattern of the sewn 60miuuts after test meal loading at 5 weeks after IJT had a main peak which correspondes glycentin Histological examination revealcd intestinal mueosal bypertrophy in all part of small in testin as well as interposed ileal segment.14weeks after IJT.There was a significant difference in crypt-villasratis betweein IJT group and sham group. Study of glucose evoked potential dffeunce showed thetfhelecxls 100m M PD and PDmax were byher in fheileum than the jejunm, preopedtuel Ater operution, the euels jtranposed ilerl segment were deercasid and unschid preoperatuil beuels of the jejumcm.In rats,the levels of sewm GLI gli increased during 20 days ofter IJT. The CORR keptbuylr leuel. Villus bupurtsoply was obsewed 10 days after IJT but it dsippcareed 40 day ofter IJT. ontheotirhand stlclp of jlucore eusbeed PO showed thet bevel of Ktinaeerg 40 days spter IJT.

本文用犬和大鼠研究了回肠转位术（IJT）或术后肠道适应性的影响。杂种犬术后5、12周和6个月观察高肠溶蛋白血症。术后第5周，肠吻合口60min的胃肠道充盈模式出现一个与甘氨酸相对应的主峰，术后第14周组织学检查显示，小肠及间置回肠段肠粘膜均出现肥大，隐窝绒毛与假手术组相比有显著性差异。葡萄糖诱发电位差异的研究表明，回肠的100mMPD和PDmax均高于空肠，术前回肠的100mMPD和PDmax均高于空肠，空肠的100mMPD和PDmax均高于回肠。Corr keptbuylr leuel. IJT后10天观察到有绒毛，但IJT后40天绒毛消失。光镜下观察到40天后，光镜下观察到的光镜下

项目成果

Iwas Sasaki: Tohoku.J.exp.Med.151. 419-428 (1987)

佐佐木岩：Tohoku.J.exp.Med.151。