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An experimental study on the correlation between immunosuppression following liver transplantation for liver cancer and tumor growth

肝癌肝移植后免疫抑制与肿瘤生长相关性的实验研究

基本信息

批准号：
62570615
负责人：
TSUZUKI Toshiharu
金额：
$ 1.09万
依托单位：
School of Medicine, Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570615/
关键词：
liver cancer progression liver transplantation 移植免疫抑制

项目摘要

It is an important problem whether immunosuppression following lover transplantation for liver cancer accelerates tumor growth and induces metastases. In order to clarify the point at issue, an experimental stury was carried out with the use of Wistar rats and the following results were obtained.1. In five rats fed on diet mixed with 3-methyl-4-diaminoazobenzene (DAB), hepatoma developed after feeding for 20 weeks. Whereas hepatoma developed in 1 of 4 rats fed on diet mixed with DAB and Cyclosporin A (Cy A) after 12 weeks. Thus, it was suggested that hepatoma developed in shorter period in rats fed on diet with the immunosuppressive drug.2. Effect of immunosuppression on tumor growth was studied on rats in which rat hepatoma (H-35) cells were injected into the liver. Tumor growth was compared between two groups of rats fed on diets mixed with or without Cyclosporin A. Rats fed on diet with Cy A had larger tumors compared with those fed on normal diet in the examinations performed on 11, 16 and 21 P.O. day.Histologic examinations revealed the difference between the two groups; cancer cells were destroyed in the 8 rats fed on normal diet on 16 and 21 P.O. day, whereas "live" cancer cells were persistent in 1 of 4 rats and in 2 of 4 rats fed on diet with Cy A on 16 and 21 p.o. day respectively. Thus, it was shown that immunosuppression may facilitate tumor growth.

肝癌肝移植后免疫抑制是否会促进肿瘤生长和诱导转移是一个重要的问题。为了阐明这一问题，我们用Wistar大鼠进行了一项实验研究，得到了以下结果.在5只喂食含3-甲基-4-二氨基偶氮苯（DAB）饲料的大鼠中，喂食20周后发生肝癌。12周后，4只大鼠中有1只发生肝癌。因此，提示免疫抑制剂组大鼠肝癌发生时间较短.将大鼠肝癌（H-35）细胞注入大鼠肝脏，研究了免疫抑制对肿瘤生长的影响。比较了两组喂食含或不含环孢菌素A饲料的大鼠的肿瘤生长情况。在术后11、16和21天进行的检查中，与正常饮食喂养的大鼠相比，喂食Cy A饮食的大鼠具有更大的肿瘤。组织学检查揭示了两组之间的差异;在P.O. 16和21，在正常饮食喂养的8只大鼠中癌细胞被破坏。而“活的”癌细胞在16和21 p.o.时在4只大鼠中的1只和4只喂食Cy A饮食的大鼠中的2只中持续存在。天分别。因此，表明免疫抑制可促进肿瘤生长。