EFFECT OF THE ORGANS AND TISSUES IN THE SPLANCHNIC AREA ON THE BIODEGRADATION OF HALOTHANE

在手术切除胃、肠和网膜的狗中，用1%氟烷麻醉3小时后，连续10天测定尿和胆汁中氟的排泄量。切除器官的重量仅相当于体重的7%。然而，与对照组相比，氟烷的吸收量减少了19%。尿氟排泄量较对照组减少58%，胆汁氟排泄量与对照组无明显差异，说明内脏器官尤其是脂肪组织对氟烷的生物降解起重要作用，胆汁中氟的排泄量与尿中氟的排泄量可能不同。

Fluoride excretions in urine and bile were measured for 10 days after 3 hours of 1% halothane anesthesia in dogs whose stomach, intestine and omentum had been removed surgically. The weight of the removed organs was corresponded to only 7% of the body weight. Nevertheless, an amount of halothane absorbed was reduced by 19% compared to that in the control group. While urinary fluoride excretion was reduced by 58% compared to that in the control group, biliary fluoride excretion in bile did not differ from that in the control.From the above results, an important role of the splanchnic organs, especially the adipose tissues, on the biodegradation of halothane was clearly realized and the degradated substance excreted in the bile might be supposed to be not similar with that in urine.