EFFECT OF THE ORGANS AND TISSUES IN THE SPLANCHNIC AREA ON THE BIODEGRADATION OF HALOTHANE

内脏区域器官和组织对氟烷生物降解的影响

• 批准号: 62570712
• 负责人: SAKAI Takayuki
• 金额: $ 1.47万
• 依托单位: KAWASAKI MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570712/
• 关键词: Halothane; Biodegradation; Urinary fluoride excretion; 胆汁中弗素排泄; 吸入麻酔薬; 弗素; 代謝

Fluoride excretions in urine and bile were measured for 10 days after 3 hours of 1% halothane anesthesia in dogs whose stomach, intestine and omentum had been removed surgically. The weight of the removed organs was corresponded to only 7% of the body weight. Nevertheless, an amount of halothane absorbed was reduced by 19% compared to that in the control group. While urinary fluoride excretion was reduced by 58% compared to that in the control group, biliary fluoride excretion in bile did not differ from that in the control.From the above results, an important role of the splanchnic organs, especially the adipose tissues, on the biodegradation of halothane was clearly realized and the degradated substance excreted in the bile might be supposed to be not similar with that in urine.

对切除胃、肠、大网膜的犬进行1%氟烷麻醉3小时后，连续10天测定其尿液和胆汁中氟化物的排泄量。被切除器官的重量仅占体重的7%。然而，与对照组相比，氟烷的吸收量减少了19%。与对照组相比，尿氟排泄量减少了58%，但胆汁中胆氟排泄量与对照组没有差异。从以上结果可以清楚地认识到内脏器官，特别是脂肪组织在氟烷生物降解中的重要作用，并且可以认为胆汁中排出的降解物质与尿液中的降解物质不相似。

项目成果

酒井 資之: 麻酔と蘓生. 24. (1988)

Mobuyuki Sakai：麻醉与 Ousei 24。（1988）

酒井資之: 麻酔. 3 7 (12). 1478-1483 (1988)

Moneyuki Sakai：麻醉 3 7 (12)。

酒井 資之: 麻酔.

酒井茂之：麻醉。

SAKAI, TAKAYUKI: "THE EFFECT OF REMOVAL OF THE ORGANS IN THE SPLANCHNIC AREA ON THE BIODEGRADATION OF HALOTHANE IN DOGS" THE JAPANESE JOURNAL OF ANESTHESIOLOGY. 37(12). 1478-1483 (1988)

SAKAI，TAKAYUKI：“内脏区域器官切除对狗体内氟烷生物降解的影响”《日本麻醉学杂志》。

酒井資之: 麻酔. 37(12). 1478-1483 (1988)

Moneyuki Sakai：麻醉 37(12)。