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OBJECTIVE JUDGEMENT ON THE INFLUENCE OF DRUGS FOR THE MALE SEXUAL FUNCTION

药物对男性性功能影响的客观判断

基本信息

批准号：
62570735
负责人：
SHIRAI Masafumi
金额：
$ 0.9万
依托单位：
TOHO UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

WITH THE PURPOSE OF DETERMINING OBJECTIVELY THE INFLUENCE OF DRUGS EXERTED ON THE MALE SEXUAL FUNCTION, STUDY HAS BEEN MADE WHETHER CORRECT JUDGEMENT OF DRUGS IS POSSIBLE OR NOT BY MEANS OF QUESTIONNAIRE REGARDING SEXUAL FUNCTION BY HAVING THE PATIENTS WITH PROSTATIC HYPERTROPHY ENTER THE QESTIONNAIRE BEFORE AND AFTER ADMINISTERING TO THEM ANTIANDROGENS (CHLORMADINONE ACETATE OR ALLYLESTRENOL) WHICH WERE IDENTIFIED PRELIMINARILY TO EXERT INFLUENCE ON THE MALE SEXUAL FUNCTION. AS A RESULT, IT WAS FOUND THAT THE QUESTIONNAIRE REGARDING SEXUAL FUNCTION USED THIS TIME PROVIDES GOOD JUDGEMENT ON THE INFLUENCE OF DRUGS EXERTED ON THE MALE SEXUAL FUNCTION. HOWEVER, THE TEST THROUGH QUESTIONNAIRE IS PROBLEMATIC IN THE ASPECT OF OBJECTIVITY, FOR WHICH IT WAS DECIDED THAT ERECTILE CONDITION WAS RECORDED BY AN ERECTIOMETER. HOWEVER, THE ERECTIOMETER POSES PROBLEMS THAT SUSTAINED TIME AND FREQUENCY OF ERECTION CAN NOT BE MEASURED, THOUGH IT CAN RECORD THE MAXIMUM EXTENTION OF THE PENILE DIAMETER AMONG CASES. THEREFORE, WE HAVE DEVELOPED A SUBMINIATURE ERECTILE RECORDING APPARATUS BY THE USE OF IC MEMORY CARD WHICH CAN BE LENT OUT TO PATIENTS AND IS MAKING ASSESMENT THE INFLUENCE EXERTED ON NOCTURNAL PENILE TUMESCENCE(NPT) WHEN DRUGS HAVE BEEN ADMINISTERED FOR MORE THAN DEFINITE PERIODS. THIS RECORDER IS VERY EASY FOR ATTACHMENT AND ALSO CONVENIENT FOR MAKING ANALYSIS OF THE DATA RECORDED ON IC MEMORY CARD, FROM WHICH IT IS CONSIDERED THAT OBJECTIVE JUDGEMENT OF DRUG INFLUENCE ON NPT IS POSSIBLE WITH THIS PAPPARATUS.

为了进一步研究药物对男性性功能的影响，通过对前列腺增生症患者在服用抗雄激素药物前后进行性功能问卷调查，研究是否可以正确判断药物（醋酸氯地孕酮或烯丙雌醇），初步确定对雄性性功能有影响。结果发现，本次使用的性功能问卷能够很好地判断所用药物对男性性功能的影响。然而，通过问卷进行的测试在勃起方面存在问题，因此决定通过勃起仪记录勃起状况。然而，勃起仪存在的问题是，虽然它可以记录阴茎直径的最大延伸范围，但无法测量持续时间和勃起频率。为此，我们研制了一种可供病人使用的IC记忆卡亚微型勃起功能记录仪，用于评价用药超过一定时间后对夜间阴茎勃起（NPT）的影响。该记录仪易于安装，也便于对IC存储卡上记录的数据进行分析，由此认为使用该记录仪可以客观判断药物对NPT的影响。