Comparative Study on Cancer in Japanese, Koreans in Japan and Koreans in Korea

韩国男性和女性的肝癌发病率几乎是日本的2倍。在日本的韩国女性似乎在本国维持着这种疾病的高风险。但是，在日本的韩国男性患肝癌的风险比在韩国的预期要高得多。由于在日本和韩国的韩国人的乙肝病毒阳性率都高于日本人，因此在日本生活的韩国人患肝癌的风险增加可能部分归因于乙肝病毒感染，尤其是韩国女性。对日本和韩国男性韩国人的病例对照研究结果表明，HBV感染是导致韩国男性肝癌的主要因素，而饮酒在日本男性韩国人患肝癌的过程中更为重要。基于手术切除标本的病理研究显示，韩国人和日本人在肝细胞癌的组织学上没有显著差异，但韩国大多数肝细胞癌患者都是HBs-Ag阳性。

Incidence rates of liver cancer in both males and females were nearly 2-fold higher in Korea than in Japan. Female Koreans in Japan appear to sustain the high risk of this disease in their home country. But male Koreans in Japan have much higher a risk of liver cancer than expected from the rate in Korea. Because prevalence of HBs-Ag positives is higher among Koreans in both Japan and Korea than among Japanese, the increased risk of liver cancer among Koreans living in Japan could be partly attributed to HBV infection, particulary with female Koreans.Resutls of case-control studies on male Koreans in Japan and Korea indicate that HBV infection is a predominant factor in the causation of liver cancer among men in Korea while alcohol drinking is more important in the development of this cancer in male Koreans living in Japan.Pathological studies based on surgically removed specimens showed no remarkable difference in the histology of hepatocellular carcinoma between Koreans and Japaneses, but the majority of patients with hepatocellular carcinoma in Korea were HBs-Ag positive.