Study on Liver Cancer among Korean Migrants in Japan.

在日本的日本人（JJ）、在韩国的韩国人（KK）和在日本的韩国人（KJ）肝癌（HCC）的比较研究显示，在3个人群中存在一些重要的差异，描述性研究显示，KJ的HCC死亡率高于JJ，男性为3倍和2倍，KK的发病率几乎是JJ的2倍。KK和KJ的RBsAg阳性率高于JJ。结果表明，韩国人肝癌的风险增加可能部分归因于HBV感染。病例对照研究结果表明，HBV感染是KK人肝癌的主要致病因素，而HCV感染在JJ人中更为重要。大量饮酒与KJ和JJ发生HCC的风险增加有关，但与KK无关。HCC抗体阳性显示出有趣的差异。JJ HCC患者的阳性率（71%）明显高于KK（首尔为20%，釜山为9%），而KJ男性患者的阳性率与JJ相似，但女性患者的阳性率与KK相同。在健康人群中，KJ、大坂和福冈的阳性率分别为6.6%和5.7%，男性和女性分别为12.5%和6.9%，高于首尔和JJ的KK（约1-2%）。然而，釜山的肝细胞癌发病率很高，男女合计为5.1%。病理学研究表明，韩国人和日本人的肝细胞癌组织学无显著差异。然而，在韩国标本中观察到更多的HBsAg阳性癌细胞和更多和严重的肝细胞异型增生，发现在日本标本。肝细胞异型增生和血清HBsAg阳性的显着关联，提示HBV感染对韩国人HCC有很强的影响。

Comparative studies on liver cancer (HCC) among Japanese in Japan (JJ), Koreans in Korea (KK) and in Japan (KJ) revealed some important diffrences between 3 populations.Descriptive studies showed higher mortality from HCC in KJ, 3 times for males and 2 times, and nearly 2-fold higher incidence rate among KK compared to JJ. Proportions of RBsAg positives were higher among KK and KJ than among JJ. The results suggest the increased risk of HCC among Koreans could be partly attributed to HBV infections.Results of case-control studies indicate HBV infection is a predominant factor in causation of HCC among KK while HCV infection is more important among JJ. Heavy drinking relates to increased risk in development of HCC among KJ and JJ but riot among KK.HCC antibody positivity showed interesting defferences. Much higher positivity (71%) was found in JJ HCC patients that KK's (20% in Seoul and 9% in Pusan) and KJ male patient showed similar level to JJ's but female's remained same levels as KK's. Iri healthy persons the positive rates were higher in KJ, 6.6% and 5.7% in Osaka and 12.5% and 6.9% in Fukuoka for males and females respectively than KK in Seoul and JJ (about 1-2%). In Pusan, however, high rate, 5.1% for both sex together, was observed.Pathological studies showed no remarkable differences in the histology of hepatocellular carcinoma between Koreans and Japanese. However, in Korean specimens more HBsAg positive cancer cells were observed and more and severe liver cell dysplasia was found that in Japanese specimens. Marked association of liver cell dysplasia and serum HBsAg positivity was noticed suggesting strong influence of HBV infection to HCC in Koreans.