Epidemiological Survey of Metal Allergy and its Relationship with Oral Metal Restorations

金属过敏流行病学调查及其与口腔金属修复的关系

• 批准号: 01304047
• 负责人: INOUE Masayuki
• 金额: $ 7.87万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01304047/
• 关键词: Metal allergy; Qualitative analysis of samples weighing about 0.1mg; Intraoral metal restorations; EPMA; Epidemiological Survey

Sensitization and allergic lesions resulting from the metals in our living environment have often been reported. However, dentists have paid little attention so far on sensitization or dermal or mucosal lesions caused by metal restorations. We have established a team of 14 research institutions to perform patch tests with 18 kinds of dental metals and to conduct an epidemiological survey on the patch test positive subjects.Prior to the study, application of the testing solutions and reading of the skin reactions were standardized. Three meetings were held during the research period to evaluate the study, solve any problems, discuss the plan and organize the results. Patch tests were done on volunteers and patients with the total of 1, 732 subjects. Metal analysis for the intraoral restorations was done by the method developed by Inoue et al., on those patients who showed positive reactions to the patch tests. The analysis results were then compared to the patch test results to investigate the relation between the two.The following data was collected and discussions were made : (1) patch test positive/negative rates for the total subjects, (2) their differences regarding sex, age, or a kind of metal, (3) regional difference, (4) relation between an individual with patch test positive result and his/her intraoral metal restoration(s), (5) types and locations of the lesions, (6) patch test positive rate (overall and of the each metal) for the patient group, (7) difference in the patch test positive rate between the volunteer group and the patient group, (8) comparison between the patch test positive rates among the M-9, M-11 or M-13 series, and among the different concentrations of the testing solutions, (9) comparison of the results between patch tests and their confirmation tests, (10) changes in the patch test reaction during the testing period, (11) incidence rate of bandage dermatitis according to the two different bandages.

在我们的生活环境中的金属引起的致敏和过敏性病变经常被报道。然而，迄今为止，牙科医生很少关注由金属螯合物引起的致敏或皮肤或粘膜损伤。我们成立了一个由14个研究机构组成的团队，对18种牙科金属进行斑贴试验，并对斑贴试验阳性受试者进行流行病学调查。在研究之前，对试验溶液的应用和皮肤反应的阅读进行了标准化。在研究期间举行了三次会议，以评估研究，解决任何问题，讨论计划和组织结果。斑贴试验在志愿者和患者中进行，共有1732名受试者。通过Inoue等人开发的方法进行口内牙釉质的金属分析，对斑贴试验呈阳性反应的病人然后将分析结果与斑贴试验结果进行比较，以研究两者之间的关系。收集了以下数据并进行了讨论：（1）总受试者的斑贴试验阳性/阴性率，（2）他们在性别、年龄或金属种类方面的差异，（3）地区差异，（4）斑贴试验阳性的个体与他/她的口内金属修复体之间的关系，（5）病变的类型和位置，（6）斑贴试验阳性率（总体和每种金属），（7）志愿者组和患者组之间斑贴试验阳性率的差异，（8）M-9中斑贴试验阳性率之间的比较，M-11或M-13系列，以及不同浓度的供试品溶液，（9）斑贴试验及其确认试验之间的结果比较，（10）试验期间斑贴试验反应的变化，（11）根据两种不同绷带的绷带皮炎发生率。

项目成果

Masayuki Inoue, Mitsuaki Matsumura, and Takashi Minami: "Oral restorations and metal allergy" Dental Diamond. 13(5). 30-37 (1988)

Masayuki Inoue、Mitsuaki Matsumura 和 Takashi Minami：“口腔修复和金属过敏”牙科钻石。

Masayuki Inoue, Mitsuaki Matsumura: "Metal Allergy and Metals used for Dental Restorations" Medicina Philosophica. 9(5). 411-414 (1990)

Masayuki Inoue、Mitsuaki Matsumura：“金属过敏和用于牙齿修复的金属”医学哲学。

Hideya Hamano: "Fundamental Studies on Biological Effects of the Dental Metals - Nickel Dissolution, Toxicity and Distribution the Cultured Cells -" J Stomatol Soc Jpn. 59. (1992)

Hideya Hamano：“牙科金属生物效应的基础研究 - 镍的溶解、毒性和培养细胞的分布 -”J Stomatol Soc Jpn。

井上 昌幸,松村 光明,南 孝: "補綴物と金属アレルギ-" Dental Diamond. 13(5). 30-37 (1988)

Masayuki Inoue、Mitsuaki Matsumura、Takashi Minami：“假肢和金属过敏”牙科钻石。

井上 昌幸,松村 光明: "歯科用金属アレルギ-の診断と治療" 補綴臨床. 22(4). 553-563 (1989)

Masayuki Inoue，Mitsuaki Matsumura：“牙科金属过敏的诊断和治疗”修复诊所 22（4）553-563（1989）。