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Mechanism of Metal Sensitization in Dental Patients and Dental Health Professionals

牙科患者和牙科保健专业人员的金属过敏机制

基本信息

批准号：
02404075
负责人：
INOUE Masayuki
金额：
$ 6.98万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404075/
关键词：
Metal Allergy Epidemiological Study Intraoral Dental Metals Minute Sample Analysis X-ray Fluorescence Analysis 金属アレルギ-

项目摘要

There has been a notable increase in dermal and mucosal lesions due to various forms of metal allergens within our living environment. Number of such cases have been reported through mass media. Researcher and staff of dental field dealing with various types of dental alloys must have a right perspective and a thorough knowledge towards such disease. However, incidence rate nor mechanism of sensitization by dental alloys within an oral environment has not yet been revealed.In this study, the subjects were dental patients who have metal restorations, dental staff such as dentist, dental technician, or dental hygienist, and individuals who never had metal restorations or had a little chance to contact metals in their daily lives. Birth place, residential area for the recent 5 years, past history of any allergies and their symptoms, patch test results, oral conditions, and relationship between the presence of intraoral metal restorations and the sensitization rate by these metals were investigated for these subjects.An X-ray fluorescence spectroscope(XRFS) was used for the metal analysis in this study. Stability, detection limit, and the effects of different types of media towards the emitted X-ray were determined for the apparatus preceding its clinical application. The XRFS was proved to be capable of analyzing not only bulk metals, but also liquids, pastes, powders, leather goods, textiles, or those samples which require non-destructive analysis. Over 2500 samples collected from the intraoral metal restorations or living environments of the patients suspected as having metal allergies were analyzed to detect the metal allergens.

在我们的生活环境中，由于各种形式的金属过敏原，皮肤和粘膜病变显著增加。通过大众传播媒介报道了一些这类案件。牙科领域的研究人员和工作人员处理各种类型的牙科合金必须对这种疾病有一个正确的观点和全面的知识。然而，牙科合金在口腔环境中致敏的发生率和机制尚未揭示。在这项研究中，研究对象是做过金属修复的牙科病人，牙科医生、牙科技师或牙科保健员等牙科工作人员，以及从未做过金属修复或在日常生活中很少有机会接触金属的个人。调查受试者的出生地点、近5年居住地区、过敏史及症状、斑贴试验结果、口腔状况、口腔内金属修复体存在与金属致敏率的关系。本研究采用x射线荧光光谱仪（XRFS）进行金属分析。在临床应用之前，确定了仪器的稳定性、检出限和不同类型介质对发射x射线的影响。事实证明，XRFS不仅能够分析散装金属，还能够分析液体、糊状、粉末、皮革制品、纺织品或需要无损分析的样品。对疑似金属过敏患者口腔内金属修复体或生活环境中采集的2500余份样品进行分析，检测金属过敏原。