DIAGNOSIS OF METAL ALLERGY BYCOLORIMETRIC ANALYSIS OF PATCH TEST

通过斑贴试验比色分析诊断金属过敏

• 批准号: 04557084
• 负责人: INOUE Masayuki
• 金额: $ 6.34万
• 依托单位: TOKYO MEDICAL AND DENTAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557084/
• 关键词: METAL ALLERGY; DIAGNOSIS; PATCH TEST; SKIN COLOR; COLORIMETRIC ANALYSIS

Patch tests have been used to determine the existence of metal allergy, and its severity was ascertained by the change in skin color. However, it was quite difficult to accurately assess the change in skin color at times. Therefore, a new colorimetric diagnostic system capable of objectively evaluating color was developed to overcome this problem. This was made possible with the aid of a computer and spectrophotometer capable of making longitudinal colorimetric studies and analysis. When this new diagnostic approach compared to the conventional subjective one, the following characteristics were obtained for positive testing ones :1.Spectral reflectance curve was of the absorption type.2.Depth of shade(Laberheta)increased.3.A high color difference(dE)value was observed.4.According to the Munsell system, the hue moved toward YR.5.Lightness decreased and there was no change in chromaticity.According to the CIELAB color system, there was a decrease in L^*, an increase in a^*, and a decrease in b^*.In conclusion, characteristics of this new objective approach showed significant differences in dE,spectral reflectance curve, Laberheta, and L^*, a^*, b^*, and lightness when comparing the negative and positive groups.We developed the diagnostic system(diagnostic formula)of the change in skin color utilized multivariate analysis on the basis of the results.

斑贴试验已被用来确定金属过敏的存在，其严重程度是通过皮肤颜色的变化来确定的。然而，有时候很难准确评估肤色的变化。因此，一个新的比色诊断系统能够客观地评价颜色的开发，以克服这个问题。这是有可能的帮助下，计算机和分光光度计能够进行纵向比色研究和分析。当这种新的诊断方法与传统的主观方法相比时，对于阳性检测方法获得了以下特征：1.光谱反射率曲线为吸收型4.根据Munsell系统，色调向YR移动。5.亮度降低，色度没有变化。根据CIELAB颜色系统，L^* 降低，a^* 增加，B^* 降低。总之，这种新的客观方法的特征表现出dE，光谱反射率曲线，Laberheta，在阴性组和阳性组比较时，用L^*、a^*、B^* 和亮度进行比较，在此基础上，利用多元分析建立了肤色变化的诊断系统（诊断公式）。

项目成果

割田研司 他: "金属アレルギーの疫学的調査-本学学生を対象としたパッチテストについて-" 昭和歯学会雑誌. 12. 319-324 (1992)

Kenji Warita 等人：“金属过敏的流行病学调查 - 我们大学生的斑贴试验 -”昭和牙科学会杂志 12. 319-324 (1992)。

割田研司 他: "金属アレルギーの疫学的調査-本学学生を対象としたパッチテストについて" 昭和歯科学会雑誌. 12. 319-324 (1992)

Kenji Warita 等人：“金属过敏的流行病学调查 - 针对我们大学生的斑贴试验”昭和牙科学会杂志 12. 319-324 (1992)。

INOUE,MASAYUKI & NAKAYAMA,HIDEO: DENTISTRY AND METAL ALLERGY. DENTAL DIAMOND,TOKYO, 1993

井上雅之

重藤 直文 他: "金属アレルギーの口腔内アレルゲン金属除去後の経過について" 広島大学歯学雑誌. 25. 356-361 (1993)

Naofumi Shigefuji 等人：“关于金属去除后口腔过敏原的过程”广岛大学牙科杂志 25. 356-361 (1993)。

MATSUDA,TOMOKO et al.: "COLORIMETRIC ANALYSIS OF THE SKIN REACTION BY PATCH TEST" J.JPN.PROSTHODONT.SOC.38. 588-595 (1994)

MATSUDA,TOMOKO 等人：“通过斑贴试验进行皮肤反应的比色分析”J.JPN.PROSTHODONT.SOC.38。