Regulation of renin and angiotensinogen gene expression in glomerular mesangial cells.

肾小球系膜细胞中肾素和血管紧张素原基因表达的调节。

基本信息

  • 批准号:
    63570532
  • 负责人:
  • 金额:
    $ 1.34万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1988
  • 资助国家:
    日本
  • 起止时间:
    1988 至 1989
  • 项目状态:
    已结题

项目摘要

Glomerular mesangial cells are known to have receptors specific to angiotensin II, to entract in response to angiotensin II and, thus, to contribute to the regulation of glomerular filtration rates. Since it has been recently reported that mesangial cells are able to produce renin, dysfunction of mesangial cells may impair the activity of intrarenal renin-angiotensin system and, thus, produce intrarenal hemodynamic alterations characteristic to diabetes. In order to evaluate the association of the changes in intrarenal renin- angiotensin system with hemodynamic alterations in diabetes, messenger RNA levels of renin and angioten- sinogen and angiotensin converting enzyme (ACE) activity in cultured mesangial cells and in kidneys of diabetic rats were examined.Neither messenger RNA of renin or angiotensinogen nor ACE activity was detected in glomerular mesangial cells cultured under various conditions, indicating that mesangial cells could function only as an effector of renin-angiotensin system. Messenger RNA levels of renin and angiotensinogen in kidneys of diabetic rats were not different from those in kidneys of control rats. In contrast to these results, ACE activity in kidneys (in both outer cortex and inner cortex plus outer medulla) of diabetic rats was significantly reduced compared with that of control rats.These results indicate that the main change in intrarenal renin-angiotensin system in diabetes is decrease in ACE activity, which could result in decrease in generation of intrarenal angiotensin II, leading to vasodilatation of arterioles characteristic to diabetes.
已知肾小球系膜细胞具有对血管紧张素II特异的受体,以响应血管紧张素II而吸引,从而有助于调节肾小球滤过率。近年来研究发现,肾小球系膜细胞能产生肾素,系膜细胞功能障碍可损害肾内肾素-血管紧张素系统的活性,从而引起糖尿病肾内血流动力学改变。为探讨糖尿病肾内肾素-血管紧张素系统的变化与血流动力学改变的关系,本实验检测了体外培养的肾小球系膜细胞和糖尿病大鼠肾脏中肾素和血管紧张素原信使RNA(mRNA)水平及血管紧张素转换酶(ACE)活性。提示系膜细胞仅作为肾素-血管紧张素系统的效应细胞发挥作用。糖尿病大鼠肾脏中的肾素和血管紧张素原的mRNA水平与对照组大鼠肾脏中的mRNA水平无差异。与此相反,糖尿病大鼠肾脏(外皮质和内皮质加外髓质)ACE活性均显著低于对照组,提示糖尿病肾内肾素-血管紧张素系统的主要变化是ACE活性降低,从而导致肾内血管紧张素II生成减少,导致糖尿病特征性小动脉血管舒张。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M. Haneda, R. Kikkawa, M. Togawa, S. Maeda, and Y. Shigeta: "Decreased expression of hepatic angiotensinogen gene in diabetic rats."
M. Haneda、R. Kikkawa、M. Tokawa、S. Maeda 和 Y. Shigeta:“糖尿病大鼠肝血管紧张素原基因的表达降低。”
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
S.Maeda,et al: "Reduced activity of renal angiotensinーconverting enzyme in streptozotocinーdiabetic rats."
S. Maeda 等人:“链脲佐菌素糖尿病大鼠肾血管紧张素转换酶的活性降低。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
M.Haneda,et al: "Decreased expression of hepatic angiotensinogen gene in diabetic rats."
M.Haneda 等人:“糖尿病大鼠肝脏血管紧张素原基因的表达降低。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
M.Haneda,et al: "Decreased expression of hepatic angiotensinogen gane in diabetic rats."
M.Haneda 等人:“糖尿病大鼠肝脏血管紧张素原 gane 的表达减少。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
S. Maeda, R. Kikkawa, M. Haneda, M. Togawa, D. Koya, N. Horide, N. Kajiwara, T. Uzu, and Y. Shigeta: "Reduced activity of renal angiotensin-converting enzyme in streptozotocin-induced diabetic rats."
S. Maeda、R. Kikkawa、M. Haneda、M. Tokawa、D. Koya、N. Horide、N. Kajiwara、T. Uzu 和 Y. Shigeta:“链脲佐菌素诱导的肾血管紧张素转换酶活性降低
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  • 影响因子:
    0
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HANEDA Masakazu其他文献

HANEDA Masakazu的其他文献

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{{ truncateString('HANEDA Masakazu', 18)}}的其他基金

Mechanism of glomerular abnormality by oxidative stress in diabetic nephropathy
糖尿病肾病氧化应激导致肾小球异常的机制
  • 批准号:
    13671184
  • 财政年份:
    2001
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
MOLECULAR MECHANISM OF MESANGIAL CELL DYSFUNCTION DUE TO HYPERGLYCEMIA AND GLOMERULAR HYPERTENSION
高血糖和肾小球高血压导致系膜细胞功能障碍的分子机制
  • 批准号:
    10671063
  • 财政年份:
    1998
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
IDENTIFICATION OF GENES REGULATED BY ADVANCED GLYCATION END PRODUCTS IN CULTURED GLOMERULAR MESANGIAL CELLS
培养的肾小球系膜细胞中高级糖化终产物调控的基因的鉴定
  • 批准号:
    08671147
  • 财政年份:
    1996
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
ABNORMAL SIGNAL TRUNSDUCTION IN MESANGIAL CELLS IN DIABETES
糖尿病肾小球系膜细胞信号传导异常
  • 批准号:
    06671021
  • 财政年份:
    1994
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
MOLECULAR MECHANISM OF MESANGIAL DYSFUNCTION IN DIABETES
糖尿病肾小球系膜功能障碍的分子机制
  • 批准号:
    04671471
  • 财政年份:
    1992
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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Renal Tubule-Specific Angiotensinogen Knockout Ameliorates Diabetic Kidney Disease in Type 1 Diabetic Akita Mice
肾小管特异性血管紧张素原敲除可改善 1 型糖尿病秋田小鼠的糖尿病肾病
  • 批准号:
    495591
  • 财政年份:
    2023
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    $ 1.34万
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Renal Tubule-Specific NRF2 Deletion Down-Regulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
肾小管特异性 NRF2 缺失下调 SGLT2 和血管紧张素原表达并改善秋田小鼠的 GFR 和肾脏损伤
  • 批准号:
    495599
  • 财政年份:
    2023
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    $ 1.34万
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Role of Renin-Angiotensin-Aldosterone System during sarcoidosis granuloma formation
肾素-血管紧张素-醛固酮系统在结节病肉芽肿形成过程中的作用
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    10591934
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Classical and Alternative Renin-Angiotensin System Dysregulation in Sepsis-Associated AKI: A Reverse Translation Approach
脓毒症相关 AKI 中的经典和替代肾素-血管紧张素系统失调:逆向翻译方法
  • 批准号:
    10369811
  • 财政年份:
    2022
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先兆子痫的新疗法
  • 批准号:
    10480975
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Classical and Alternative Renin-Angiotensin System Dysregulation in Sepsis-Associated AKI: A Reverse Translation Approach
脓毒症相关 AKI 中的经典和替代肾素-血管紧张素系统失调:逆向翻译方法
  • 批准号:
    10536651
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    $ 1.34万
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Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
高血压通过肾素诱导血小板-ACE2/SARS-Cov-2复合物内化增强了COVID-19
  • 批准号:
    10490385
  • 财政年份:
    2021
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Angiotensin (1-12) and Hypertension in the Elderly
血管紧张素 (1-12) 与老年人高血压
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    10370035
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    2021
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缺血性急性肾损伤长期后遗症的神经调节
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