Heterogeneity of Prolactin in Sera and CSF in Prolactinoma Patients

为了研究催乳素的异质性，采用凝胶层析法、放射免疫法、放射受体测定法和生物测定法对催乳素瘤患者的血清和脑脊液进行了研究。血清和脑脊液的层析得到三种不同相对分子质量的催乳素。放射受体分析是利用牛卵巢的受体繁殖。用大鼠NB2淋巴瘤细胞系进行生物测定。在血清中，受体法、生物法和放射免疫法之间有很好的相关性。

In order to study the heterogeneity of prolactin, sera and cerebrospinal fluid obtained from prolactinoma patients were studied employing gel chromatography, radioimmunoassay, radioreceptor assay and bioassay. Chromatography in sera and cerebrospinal fluid gave three types of prolactin with different molecular weights. Radioreceptor assay was used by using a receptor propagation from bovine ovaries. Bioassay was used by using the rat Nb_2 lymphoma cell line. In sera, there was a good correlation between receptor assay, bioassay and radioimmunoassay.