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Costal cartilage ossification and bone aging with special reference to the clinical significance

肋软骨骨化与骨老化特别参考的临床意义

基本信息

批准号：
63570707
负责人：
IIZUKA Tadashi
金额：
$ 1.34万
依托单位：
Saitama medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

1) Control study : Radiographs of the costal cartilages were examined in 253 control patients( 140 males and 113 females, 10-90 years ). The costal cartilage ossification ( CCO ) was classified into tree categories ; type I ( marginal ), type II ( central ), type III ( other ). This typing was found very useful as an indicator of sexing ; 97% cases of type I were male, and 98% of type II were female. We classified the degree of CCO into three; grade I ( less than 1/3 of costal cartilage length ), grade II ( 1/3 to 2/3 ), and grade III ( more than 2/3 ). The ossification rate and degree increased with aging, and those in female were rapider than in male. 2) Histological study ( 26 autopsied cases ): the endochondral ossification was observed in all the types of CCO. By energy-dispersive X-ray analysis with scanning electron micros copy, hydroxyapatite crystal was clarified. 3)Relationship with pathological conditions a) Osteoporosis : 58 patients were compared with 89 age-matched controls, and found that the rate and degree of CCO was statistically smaller. b) Knee meniscus calcification : 13 patients were compared with 89 age-matched controls, and found that those of CCO had no statistical difference. c) Ossification of spinal ligament: 28 patients were compared with 127 age-matched controls, and found that those of CCO was statistically larger. 4) Quantitative CT study showed that the more Ca in bone, the larger CCO. As a conclusion, CCO seemed to be a good indicator for sexing and bone quantity.

1)对照研究：对253例对照患者(男140例，女113例，年龄10~90岁)进行肋软骨X线片检查。肋软骨骨化(CCO)分为三型：I型(边缘型)、II型(中央型)、III型(其他)。这种分型被发现作为性别鉴定的指标非常有用；I型病例中97%是男性，II型病例中98%是女性。我们将CCO的程度分为三级：I级(小于肋软骨长度的1/3)，II级(1/3~2/3)，III级(大于2/3)。骨化率和骨化程度随年龄增长而增加，且女性快于男性。2)组织学观察(26例尸检)：各型CCO均可见软骨内骨化。通过X射线能谱分析和扫描电子显微镜分析，明确了羟基磷灰石的晶体结构。3)骨质疏松症与病理条件的关系：58例患者与89例年龄匹配的对照组比较，发现CCO的发生率和程度均有统计学意义。B)膝关节半月板钙化：13例患者与89例年龄匹配的对照组比较，发现CCO患者的半月板钙化程度无统计学差异。C)脊柱韧带骨化：28例患者与127例年龄匹配的对照组比较，发现CCO的骨化程度有统计学意义。4)定量CT研究显示，骨中钙含量越高，CCO越大。综上所述，CCO似乎是性别划分和骨量的良好指标。