Multichannel Spinal Cord Monitoring System

多通道脊髓监测系统

• 批准号: 63870058
• 负责人: TSUJI Haruo
• 金额: $ 5.57万
• 依托单位: Faculty of Medicine, Toyama Medical and Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63870058/
• 关键词: Spinal cord monitoring; Spinal cord ischemia; Laser; Blood pressure; Hypothermia; Spinal cord action potentials; Iatrogenic paraplegia; レ-ダ-チャ-ト; 警報システム; レ-ザ-血流計; 誘発脊髄電位; レ-ザ-ドップラ-; 脊髄血流; 低体温; 脊髄圧迫; 経頭蓋刺激誘発脊髄電位; 脊髄血液; 脊髄モニタリング; レーザー

A multichannel spinal cord monitoring system has been developed through the animal experiments using cats from 1988 to 1990. The basic study in thisproject consisted of the following researches : 1) Relationships between evoked spinal cord action pot entials (L2 descending ESCP, L5 descend ESCP, ascemndng ESCP, segmental ESCP, and motor segmental ESCP) in spinal cord ischemia and the cord dysfunction, 2) Technical problems on deliveration of direct determination of spinal cord blood flow, 3) Effects of hypothermia on spinal cord action potentials, 4) Origins and conducting tracts of evoked spinal cord potentials elicited by peripheral nerve stimulation, 5) Origins and conducting pathways of motor evoked potentials elicited by transcranial (vertex-hard palate) stimulation, and 6) Effects of epidural electrical stimulation modalities on spinal cord function and morphlogy. From the results of these basic researches, five signals were selected for evaluation of spinal cord dysfunction. The signals were consisted of amplitude changes of the two definite action potentials, spinal cord blood flow detected by laser system (in animals), and body temperature (in human). In this alarm system, these datas were put in a computer system, and automatically displayed as a radar chart with the reference. This system is thought to be able to detect the ischmic changes as well as the mechanical insults to the cord. This system composed of hard and soft wares, and the availability was confirmed for detecting cord dysfunctions during spinal cord surgery or aortic surgery in animals.

1988 ~ 1990年，我们通过猫的动物实验，研制了一套多通道脊髓监护系统。本项目的基础研究包括以下几个方面：1）诱发脊髓动作电位之间的关系（L2下行ESCP、L5下行ESCP、上行ESCP、节段性ESCP和运动节段性ESCP）在脊髓缺血和脊髓功能障碍中的作用; 2）直接测定脊髓血流量的技术问题; 3）低温对脊髓动作电位的影响;（4）周围神经刺激诱发脊髓电位的起源和传导途径;（5）经颅（顶-硬腭）刺激诱发运动诱发电位的起源和传导途径;（6）硬膜外电刺激方式对脊髓功能和形态的影响。从这些基础研究的结果中，选择了五种信号用于脊髓功能障碍的评估。信号由两个确定动作电位的幅度变化、激光系统检测的脊髓血流量（动物）和体温（人）组成。在该报警系统中，这些数据被输入计算机系统，并自动显示为雷达图与参考。该系统被认为能够检测缺血变化以及对脊髓的机械损伤。该系统由硬件和软件两部分组成，已用于动物脊髓手术和主动脉手术中脊髓功能障碍检测。

项目成果

Takakuwa K,Tsuji H,Takano H,Kitagawa H: "Effects of Epidural Electrical Stimulational Modalities on Spinal Cord Function and Morphology in Cats." Journal of Spinal Disorders. 2. 155-162 (1989)

Takakuwa K、Tsuji H、Takano H、Kitakawa H：“硬膜外电刺激方式对猫脊髓功能和形态的影响”。

Takano H, Takakuwa K, Kitagawa H, Yamamoto N, Tsuji H, Ueyama T: "Spinal cord monitoring in aortic aneurysm surgery." Spinal Cord Monitoring (ed. Shimoji) Springer-Verlag. 5 (1991)

Takano H、Takakuwa K、Kitakawa H、Yamamoto N、Tsuji H、Ueyama T：“主动脉瘤手术中的脊髓监测。”

Takano H,Kitagawa H,Yamamoto N,Takakuwa K,Tsuji H: "Origins and conducting tracts of evoked spinal cord potentials elicited by peripheral nerve stimulation in cats." Journal of spinal disorders. 4. (1991)

Takano H、Kitakawa H、Yamamoto N、Takakuwa K、Tsuji H：“猫周围神经刺激引起的脊髓诱发电位的起源和传导束。”

Kitagawa,H.;Itoh,T.;et al.: Spine.14. (1989)

Kitakawa,H.；Itoh,T.；等人：Spine.14。

Takano H,Takakuwa K,Kitagawa H Yamamoto N,Tsuji H,Ueyama T: "Spinal cord monitoring in aortic aneurysm surgery.in Spinal Cord Monitoring Ed.Shimoji K et al." SpringerーVerlag, 5

Takano H、Takakuwa K、Kitakawa H Yamamoto N、Tsuji H、Ueyama T：“主动脉瘤手术中的脊髓监测。《脊髓监测》Ed.Shimoji K 等人，5”