Twenty-four hour rhythms of the hypothalamic CRF production and release, and the afferent pathways from the light- and food-entrainable circadian oscillations.

下丘脑 CRF 产生和释放的二十四小时节律,以及光和食物夹带昼夜节律振荡的传入通路。

基本信息

  • 批准号:
    01570081
  • 负责人:
  • 金额:
    $ 1.41万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1989
  • 资助国家:
    日本
  • 起止时间:
    1989 至 1991
  • 项目状态:
    已结题

项目摘要

The purpose of the present study is to clarify the afferent pathways from the lightand food-entrainable circadian oscillations to the hypothalamic CRF neurons which play a key role in the regulation of the hypothalamus-pitultary-adrenocortical axis. The light-entrainable circadian rhythm is expressed in rats under ad libitum feeding, while the food-entrainable circadian rhythm become apparent under restricted feeding.The CRF concentrations in the paraventricular nucleus(PVN)where CRF is produced, and in the median eminence(ME)where CRF is released varied around the clock under both feeding conditions. The CRF concentration is high in the early light period and low in the early dark period under ad libitum feeding. On the other hand, the CRF concentration is low prior to the time of daily meal and increases after meal supply. The findings indicate that the food-entrainable circadian oscillation manifests itself on the functions of the CRF neurons In the PVN as well as in the ME.To clari … More fy the afferent pathway from the food-entrainable oscillation, various neurotoxic agents were microinjected into several areas In the brain. Among them, 6hydroxydopamine(6-OHDA)into the PVN or into the ascending bundle of catecholaminergic neurons in the midbrain abolished the food-entrainable circadian corticosterone rhythm.To have better understanding of the role of catecholaminergic neurons in the food-entrainable CRF rhythm, noradrenaline in the PVN was continuously monitored by means of in vivo microdialysis. As a result, noradrenaline In the PVN Increased prior to the daily meal and decreased after meal supply. The finding suggests, together with the 6-OHDA effect, that noradrenaline accelerates the pre-feeding CRF release.Neuropeptide Y(NPY)coexists with noradrenaline in the ascending catecholaminergic neurons which innervate the PVN. NPY in the PVN increased after the daily meal, which suggests the termination of NPY release. The synergistic action of NPY with noradrenaline on CRF release is most plausible. Less
本研究的目的是阐明从光和食物可携带的昼夜节律振荡到下丘脑CRF神经元的传入途径,这些神经元在下丘脑-垂体-肾上腺皮质轴的调节中起关键作用。光可携带的昼夜节律在自由喂养的大鼠中表达,而食物可携带的昼夜节律在限制喂养的大鼠中变得明显。在两种喂养条件下,产生CRF的室旁核(PVN)和释放CRF的中隆起(ME)中的CRF浓度昼夜变化。自由采食条件下,CRF浓度在光照前期高,暗前期低。另一方面,CRF浓度在每日用餐时间前较低,而在餐后增加。研究结果表明,食物可携带的昼夜节律振荡在PVN和ME的CRF神经元的功能上表现出来。为了更清楚地了解食物可携带振荡的传入途径,将各种神经毒性药物微注射到大脑的几个区域。其中,6-羟多巴胺(6-OHDA)进入PVN或进入中脑儿茶酚胺能神经元上行束,破坏了食物可携带的昼夜皮质酮节律。为了更好地了解儿茶酚胺能神经元在食物可携带的CRF节律中的作用,通过体内微透析方法连续监测PVN中的去甲肾上腺素。结果,PVN中的去甲肾上腺素在每日用餐前升高,而在餐后降低。这一发现表明,与6-羟色胺效应一起,去甲肾上腺素加速了进食前CRF的释放。神经肽Y(NPY)与去甲肾上腺素共存于支配PVN的上行儿茶酚胺能神经元中。日餐后PVN中NPY增加,提示NPY释放终止。NPY与去甲肾上腺素对CRF释放的协同作用是最可信的。少

项目成果

期刊论文数量(81)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Honma,K.: "Circadian Rhythm and Space" Biol.Sci.in Space. 3. 6-15 (1989)
Honma,K.:“昼夜节律与空间”太空生物科学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
高橋 三郎他編: "臨床時間生物学" 朝倉書店, 328 (1990)
高桥三郎等编:《临床时间生物学》朝仓书店,328(1990)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Honma, K.: "Hormones and behaviors." New Handbook of Physiology. 20. 199-203 (1990)
Honma, K.:“激素和行为。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Katusno, Y.: "Effects of restricted daily feeding on 24 hour variations of CRH and AVP in rat hypothalamic nuclei." Jpn. J. Physiol.41. S177 (1991)
Katusno, Y.:“每日限制喂养对大鼠下丘脑核中 CRH 和 AVP 24 小时变化的影响。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Hiroshige, T.: Hokkaido University Press. Circadian Clocks and Ecology, 216 (1989)
Hiroshige, T.:北海道大学出版社。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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HONMA Ken-ichi其他文献

HONMA Ken-ichi的其他文献

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{{ truncateString('HONMA Ken-ichi', 18)}}的其他基金

Food entrainable circadian rhythm in humans
食物引起的人类昼夜节律
  • 批准号:
    23390047
  • 财政年份:
    2011
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Understanding of the circadian system
了解昼夜节律系统
  • 批准号:
    15109004
  • 财政年份:
    2003
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
Development of multidimensional real-time monitoring system for neuronal activity by plural bioluminescent reporters
多元生物发光报告基因多维神经元活动实时监测系统的开发
  • 批准号:
    12558091
  • 财政年份:
    2000
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Dual oscillator structure of human biological clock: Oscillation coupling between the circadian rhythms and sleep-wake cycle and the sites of oscillation
人体生物钟的双振子结构:昼夜节律和睡眠-觉醒周期之间的振荡耦合以及振荡部位
  • 批准号:
    10470014
  • 财政年份:
    1998
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional structure of human biological clock : Oscillation coupling and roles of melatonin in the two-oscillator model
人体生物钟的功能结构:双振荡器模型中的振荡耦合和褪黑激素的作用
  • 批准号:
    08457018
  • 财政年份:
    1996
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Novel effects of light on central nervous system-Characteristics of non-visual photoactions and retinosuprachiasmatic complex
光对中枢神经系统的新作用-非视觉光作用和视交叉上复合体的特征
  • 批准号:
    06304025
  • 财政年份:
    1994
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Co-operative Research (A)
Systematic Analysis of Biological Timing
生物时序的系统分析
  • 批准号:
    05044141
  • 财政年份:
    1993
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for international Scientific Research

相似海外基金

Neuronal and homeostatic regulation of sleep and wake by corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus
下丘脑室旁核中促肾上腺皮质激素释放激素神经元对睡眠和觉醒的神经元和稳态调节
  • 批准号:
    10464942
  • 财政年份:
    2022
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  • 项目类别:
Neuronal and homeostatic regulation of sleep and wake by corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus
下丘脑室旁核中促肾上腺皮质激素释放激素神经元对睡眠和觉醒的神经元和稳态调节
  • 批准号:
    10708773
  • 财政年份:
    2022
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    $ 1.41万
  • 项目类别:
Immunotherapeutic Targeting of Corticotropin-Releasing Hormone in Alzheimer's Disease
促肾上腺皮质激素释放激素在阿尔茨海默病中的免疫治疗靶向
  • 批准号:
    9469597
  • 财政年份:
    2017
  • 资助金额:
    $ 1.41万
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Immunotherapeutic Targeting of Corticotropin-Releasing Hormone in Alzheimer's Disease
促肾上腺皮质激素释放激素在阿尔茨海默病中的免疫治疗靶向
  • 批准号:
    9765429
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    2017
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The role of corticotropin releasing hormone in acquisition of motor learning
促肾上腺皮质激素释放激素在运动学习获得中的作用
  • 批准号:
    16K16486
  • 财政年份:
    2016
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Role of Corticotropin Releasing Hormone in Intestinal Inflammation
促肾上腺皮质激素释放激素在肠道炎症中的作用
  • 批准号:
    8885497
  • 财政年份:
    2015
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    $ 1.41万
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Role of Corticotropin Releasing Hormone in Intestinal Inflammation
促肾上腺皮质激素释放激素在肠道炎症中的作用
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    9118984
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Understanding the role of the brain CRH (Corticotropin-Releasing Hormone) system in the detection and consumption of nutritional sugar.
了解大脑 CRH(促肾上腺皮质激素释放激素)系统在营养糖检测和消耗中的作用。
  • 批准号:
    9070673
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    2015
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    26750240
  • 财政年份:
    2014
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Effect of intra-venous corticotropin releasing hormone (CRH) on esophageal physiological changes in NERD patients.
静脉注射促肾上腺皮质激素释放激素(CRH)对NERD患者食管生理变化的影响。
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