Evaluation of Sequential Change of Myocardial Elasticity in Hypertrophic Cardiomyopathy by Non-Invasive Vibration Method.

通过Advani-Lee或量纲分析外推理论方程，发展了一种估计左室心肌弹性的新的临床方法。介绍了一种无创测量人体单位心肌弹性(杨氏模数)的方法。因为这些方程只需要非侵入性的振型、固有频率和尺寸参数。在比较Advani-Lee或量纲分析的单位弹性与物理厚壁球形模型中标准拉伸试验的结果验证新方法的有效性后，将该方法应用于估计肥厚型心肌病(HCM)患者心肌弹性的变化，用参数谱估计(时间相关AR建模法)计算左室特征频率，并用超声心动图或左室造影法测量左室壁厚度和内径。肥厚型心肌病患者的左室舒张末心肌弹性大于正常人。因此，肥厚性心肌病患者左心室顺应性的降低似乎源于心肌弹性的增加。

New clinical method for estimating left ventricular myocardial elasticity has been developed by extrapolation the theoretical equation by Advani-Lee or the dimension analysis. Human elasticity per unit myocardium (Young's modulus) can be measured non-invasively by introducing this method. Because these equation only requires non-invasive parameters of vibration mode, eigenfrequency and dimensions. After verifying the validity of this new method by comparing the unit elasticity by Advani-Lee or dimension analysis with those by standard stretch test in the physical thick-walled spherical model, this method was applied to estimate the change in myocardial elasticity in patients with hypertrophic cardiomyopathy (HCM), calculating left ventricular eigenfrequency by parametric spectrum estimation (time dependent AR modeling method) and measuring left ventricular wall thickness and dimensions by echocardiography or by left ventriculography. Left ventricular end-diastolic myocardial elasticities of HCM patients were greater than those of normal subjects. Therefore, the decrease in left ventricular compliance in HCM patients seemed to arise from an increase in myocardial elasticity.