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Prenatal Evaluation of Lung Hypoplasia and Circulatory Failure in Fetal Diaphragmatic Hernia

胎儿膈疝肺发育不全及循环衰竭的产前评估

基本信息

批准号：
01570712
负责人：
KAMATA Shinkichi
金额：
$ 0.51万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570712/
关键词：
Fetus Diaphragmatic Hernia Lung Hypoplasia Circulatory Failure Prenatal Evaluation

项目摘要

Fetal diaphragmatic hernia was experimentally made by using 12 pregnant Japanese goats from 100 to 120 days in gestation. Under general anesthesia with fluothane. fetuses were identified in uterus after laparotomy. Left diaphragm was surgically opened through laparotomy in one fetus and the other fetus was treated as a control. if twin pregnancy. In 6 fetuses survived more than 1 week after surgical creation of diaphragmatic hernia and 4 their controls. measurements of lung /thorax transverse area ratio (L/T) and Doppler examination were serially performed by fetal ultrasound and lung/body weight ratio. radial alveolar counts and lecithin/sphingomyelin ratio in the lung were examined at autopsy.L/T gradually decreased after operation and a statistillay significant difference was observed to the controls at the final measurements (0.41<plus-minus>0.07 vs 0.58<plus-minus>0.04). Although no significant difference was noted in lung/body weight ratio (0.019<plus-minus>0.005 vs 0.025<plus-minus>0.006). a significant correlation was observed between L/T and lung/body weight ratio. Radial alveolar counts significantly decreased in the left lung of diaphragmatic hernia models compared to the right lung. However, no significant difference was observed between lecithin/sphingomyelin ratio of the left and right lung. Doppler examination revealed no significant difference between diaphragmatic hernia models and the cThese results indicated that measurements of lung/thorax transverse area ratio by fetal ultrasound should be useful for the assessment of lung hypoplasia in fetal diaphragmatic hernia.

使用12只怀孕100至120天的怀孕日本山羊进行胎儿膈疝实验。在氟烷全身麻醉下。剖腹手术后在子宫内发现胎儿。通过剖腹手术打开一个胎儿的左膈肌，另一胎儿作为对照。如果是双胞胎怀孕。膈疝手术后，6 名胎儿存活超过 1 周，对照组胎儿 4 名。通过胎儿超声和肺/体重比连续进行肺/胸廓横面积比（L/T）测量和多普勒检查。尸检时检查肺内径向肺泡计数和卵磷脂/鞘磷脂比值。术后L/T逐渐下降，最终测量结果与对照组有统计学显着性差异（0.41±0.07 vs 0.58±0.04）。尽管肺/体重比没有显着差异（0.019<正负>0.005 vs 0.025<正负>0.006）。 L/T 和肺/体重比之间观察到显着相关性。与右肺相比，膈疝模型左肺的径向肺泡计数显着减少。然而，左肺和右肺的卵磷脂/鞘磷脂比率没有观察到显着差异。多普勒检查显示膈疝模型与对照组之间没有显着差异。这些结果表明，通过胎儿超声测量肺/胸廓横面积比应有助于评估胎儿膈疝的肺发育不全。