Control of Organ Specific Metastasis

器官特异性转移的控制

• 批准号: 01570828
• 负责人: UDAGAWA Eiichi
• 金额: $ 1.41万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570828/
• 关键词: Metastasis; Organ Specificity; Autonomic Growth; Growth Control; Tumor Markers; Bone Metastasis; Screening Test; 自律的増殖; 分裂コントロ-ル

Metastasis may be considered to be an no-stochastic process. Proliferation of malignant tumors is based on a internal autonomy of cells. Suppressor factors which are produced by host may not play so important roles in growth control of malignant tumors, since autonomic proliferation of tumor cells is programmed internally. Control mechanism in multicellular organisms is essentially to maintain cell society. Furthermore, tumor heterogeneity is induced by internal evolution of cells.Tumor markers do not demonstrate prognosis in general, since prognostic factors are complicated. However, the diagnositc value of markers is practically high in screening test for carcinomas. Combination of independent markers is suitable for the diagnosis of them, since false positive results may be excluded using independent markers.

转移可以被认为是一个非随机过程。恶性肿瘤的增殖是基于细胞的内部自主性。由于肿瘤细胞的自主增殖是内源性的，宿主产生的抑制因子在恶性肿瘤的生长调控中可能不起重要作用。多细胞生物的控制机制本质上是维持细胞社会。此外，肿瘤异质性是由细胞内部进化引起的，肿瘤标志物一般不能反映预后，因为预后因素复杂。但在肿瘤的筛查试验中，标记物的诊断价值实际上是很高的。独立标志物的组合适用于它们的诊断，因为使用独立标志物可以排除假阳性结果。

项目成果

Chigira,M.& Shinozaki,T.: "Diagnostic Value of Serum Tumor Markers in Skeletal Metastasis of Carcinomas" Arch.Orthop.Traumato.Surg.109. 247-251 (1990)

奇吉拉，M.

Chigira,M.: "Freedom from Wholism in Multicellular Organisms: A Possible role of tumor suppressor genes" Medical Hypotheses.

Chigira,M.：“多细胞生物体中的整体主义的自由：肿瘤抑制基因的可能作用”医学假设。

Chigira,M.: "Tumor Progression and Geneーdeletion in the ´neutral´ evolution of Clones" J.Theoretical Biol.

Chigira, M.：“克隆‘中性’进化中的肿瘤进展和基因缺失”J.Theoretical Biol。

Masaki Chigira,et al.: "Autonomy in tumor cell proliferation" Medical Hypotheses. 30. (1990)

Masaki Chigira 等人：“肿瘤细胞增殖的自主性”医学假设。

Chigira,M.et al.: "No Correlation between Tumor Markers and Prognaosis under Polygenic Control Systems" Medical Hypotheses. 32. 245-248 (1990)

Chigira,M.等人：“多基因控制系统下肿瘤标志物与预后之间没有相关性”医学假设。