Control of Organ Specific Metastasis

转移可能被认为是一个非随机过程。恶性肿瘤的增殖是以细胞的内部自主性为基础的。由于肿瘤细胞的自主增殖是由体内编程的，因此宿主产生的抑制因子在恶性肿瘤的生长控制中可能起不到重要的作用。多细胞生物的控制机制本质上是维持细胞社会。此外，肿瘤异质性是由细胞内部进化引起的。肿瘤标志物一般不能显示预后，因为预后因素是复杂的。然而，在肿瘤的筛选试验中，标记物的诊断价值实际上是很高的。独立标记的组合适合于诊断，因为使用独立标记可以排除假阳性结果。

Metastasis may be considered to be an no-stochastic process. Proliferation of malignant tumors is based on a internal autonomy of cells. Suppressor factors which are produced by host may not play so important roles in growth control of malignant tumors, since autonomic proliferation of tumor cells is programmed internally. Control mechanism in multicellular organisms is essentially to maintain cell society. Furthermore, tumor heterogeneity is induced by internal evolution of cells.Tumor markers do not demonstrate prognosis in general, since prognostic factors are complicated. However, the diagnositc value of markers is practically high in screening test for carcinomas. Combination of independent markers is suitable for the diagnosis of them, since false positive results may be excluded using independent markers.