A new approach to the diagnosis of Endometrial Carcinoma - P-450HFLa and PP 4 -

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Immunohistochemical (ABC method) and immunoserological (EIA) investigations of P-450HFLa and PP4 demonstrated the followings during the period of 1989-1991.1.P-450HFLa(1) This enzyme was age-dependent immunohistochemically in the human fetal livers, and clearly localized in the human placental villi. P-450HFLa was also localized in 86% of endometrial carcinomas.(2) Its normal serum upper level was 3 u/ml (mean+2 sigma) . Serum values were not related to menstrual cycles, while the concentrations were elevated in 93% of late pregnancies.(3) Although its pretherapeutic serum positive rates (>3u/ml) remained 10% in benign gynecologic diseases, the rates were 100% in endometrial carcinomas. 2.PP4(1) PP4 was demonstrated immunohistochemically in human and cynomolgus placental villi and decidua. This protein was localized clearly in the endometrial stromal cells, while PP4 was demonstrated in 20% of endometrial cancers.(2) Its normal serum upper limit was 10.9 ng/ml ( mean+2 sigma). Serum concentrations were elevated in the luteal phase and amniotic fluids, and lowered markedly in the late pregnancy.(3) Its serum positive rates remained 18% in benign gynecologic diseases, but elevated up to 47% even in the 1st stage (FIGO) of endometrial carcinomas.The above-mentioned data suggest a certain possibility that these two fetoplacental proteins could serve as a tumor marker for endometrial carcinoma.