Risk factors for HCV vertical transmission -with special reference to maternal HCV/HIV double carrier-state-

1997年的研究结果如下：1)HCV垂直传播的危险因素；HCV VT最突出的危险因素应该是母亲HCV和HIV双重携带者状态，或母亲静脉吸毒成瘾。此外，本研究还证明了另一个有价值的危险因素，分娩时母体ALT水平（110 IU/ml）。2)携带婴儿的结局：几乎一半的携带婴儿（持续HCV-RNA阳性超过6个月）血液循环中出现HCV-RNA（-）的时间较长（最长48 Ms）。3)与丙型肝炎病毒（HGV）的关系HCV/HGV阳性母亲所生的婴儿出现HGV携带者状态的比例较高（50%），说明母亲HCV/HGV双携带者状态是母婴感染HGV的危险因素之一。

The results obtained in 1997 are as follows :1) Risk factors for HCV vertical transmission (VT) ;The most prominent risk factors for HCV VT should be maternal double carrier-state for HCV and HIV,or maternal intravenous drug addiction. In addition, this study demonstrated one more risk valuable risk factor, maternal ALT levels at delivery (110 IU/ml).2) Outcome of the carrier infantsAlmost half of the carrier infants (persistent HCV-RNA-positive more than 6 months) became HCV-RNA (-) in their blood circulation for long periods (48 Ms, at longest).3) Relation to Hepatitis G virus (HGV)The infants born to HCV/HGV-positive carrier women developed HGV carrier-state highly (50%) , which means maternal double carrier-state for HCV/HGV is one of risk factors for HGV materno-infantile infection.