Investigations into the antibacterial mechanism of action of cannabidiol

大麻二酚抗菌作用机制的研究

• 批准号: DP240102291
• 负责人: Prof Mark Blaskovich
• 金额: $ 41.37万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102291
• 关键词: Investigations; into; antibacterial; mechanism; action

Cannabidiol (CBD) comes from a set of naturally occurring compounds, with a range of applications in mainstream culture. We have recently reported that CBD has excellent antimicrobial properties, with the ability to kill bacteria. This project aims to understand how CBD works by examining CBD-bacterial interactions at a genetic and molecular level. By understanding how CBD acts on and within bacterial cells, we can create fundamental new knowledge that could lead to the design of improved analogs of CBD to that can treat bacterial infections. As a much-needed completely new antibiotic class, this will lead to significant benefits, supporting Australia's National Strategy to combat the challenges posed by antimicrobial resistance.

大麻二酚（CBD）来自一组天然存在的化合物，在主流文化中有一系列应用。我们最近报道说CBD具有优异的抗菌性能，能够杀死细菌。该项目旨在通过在遗传和分子水平上研究CBD-细菌相互作用来了解CBD如何工作。通过了解CBD如何作用于细菌细胞及其内部，我们可以创造新的基础知识，从而设计出可以治疗细菌感染的CBD类似物。作为一种急需的全新抗生素类别，这将带来重大利益，支持澳大利亚应对抗菌素耐药性带来的挑战的国家战略。