Fast Protein Crystallographic Refinement System Using 3D Computer Graphics System with Built - in CPU.
Fast Protein Crystallographic Refinement System Using 3D Computer Graphics System with Built - in CPU.
批准号:
01880031
负责人:
MITSUI Yukio
金额:
$2.94万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B).
财政年份:
1989
资助国家:
日本
项目状态:
已结题
起止时间:
1989 至 1990
中文摘要
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英文摘要
1.3D computer graphics "IRIS" with built - in CPU was purchased. After checking the basic performance, molecular display program QUANTA and molecular mechanics program CHARMM have been installed and made active.2. The program "FRODO" has been transplanted from Vector General graphics system to IRIS graphics system making possible the prompt interpretations of protein electron density maps.3. Using the above hard - and soft - ware systems, the structures of murine interferon, ribonuclease Ms complexed with 3'GMP and SSI-subtilisin complex have been successfully refined.4. Through the achievements described in 3. Above, the usefulness of the system developed here has fully been proved.
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Y. Takeuchi , K. T. Nakamura , Y. Mitsui et al.: "Refined crystal structure of the complex of subtilisin and SSI" J. Mol. Biol.
Y. Takeuchi、K. T. Nakamura、Y. Mitsui 等人:“枯草杆菌蛋白酶和 SSI 复合物的精制晶体结构” J. Mol。
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发表时间:
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作者:
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通讯作者:
Y.Takeuchi,S.KojiMa,K.Miura,Y.Mitsui: "Molecular Recognition at the Active Site of Subtilisin BPN′" Protein Engineering. (1991)
Y.Takeuchi、S.KojiMa、K.Miura、Y.Mitsui:“枯草杆菌蛋白酶 BPN 活性位点的分子识别”蛋白质工程(1991)。
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熊谷 泉,竹内 康雄,三井 幸雄,三浦 謹一郎: "プロテア-ゼとプロテア-ゼ・インヒビタ-" シリ-ズ 分子生物学の進歩 3.蛋白質の件能構増. 219-241 (1990)
Izumi Kumagai、Yasuo Takeuchi、Yukio Mitsui、Kinichiro Miura:“蛋白酶和蛋白酶抑制剂”系列分子生物学进展3.蛋白质功能结构的增加219-241(1990)。
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作者:
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通讯作者:
Y.Takeuchi,K.T.Nakamura,Y.Mitsui: "Refined Crystal structure of the Complex of Subtilisin and SSI" J.Mol.Biol.(1991)
Y.Takeuchi、K.T.Nakamura、Y.Mitsui:“枯草杆菌蛋白酶和 SSI 复合物的精制晶体结构”J.Mol.Biol.(1991)
DOI:
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发表时间:
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作者:
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通讯作者:
Y.Takeuchi,S.Kojima,K.Miura,Y.Mitsi: "Molecular Recognition at the Interface between Subtilisin and SSI" Protein Engineering (M.Ikehara ed.) Japan Scientific Societies Press. 103-108 (1990)
Y.Takeuchi、S.Kojima、K.Miura、Y.Mitsi:“枯草杆菌蛋白酶和 SSI 之间界面的分子识别”蛋白质工程(M.Ikehara 编)日本科学会出版社。
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共 17 条
Elucidation of the reaction mechanism of a PCB-degrading enzyme BphyC based on three-dimensional structural information.
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批准号:07458251
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.15万
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财政年份:1995
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负责人:MITSUI Yukio
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依托单位:
New rapid method of protein crystal structure analyzes making use of protein engineering techniques
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批准号:07559006
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资助金额:$4.03万
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财政年份:1995
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负责人:MITSUI Yukio
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依托单位:
Elucidation of the steric bases of anticancer activities of interferons through a combined approach by X-ray crystal structure analyzes and protein engineering.
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资助金额:$14.08万
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财政年份:1992
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负责人:MITSUI Yukio
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依托单位:
Development of a system for rapid protein structure
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批准号:03558017
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$5.95万
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财政年份:1991
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负责人:MITSUI Yukio
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依托单位:
Crystallographic Studies on Protease ー Substrate Interaction Using Genetically - Engineered Inhibitors.
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批准号:01480516
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.88万
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财政年份:1989
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负责人:MITSUI Yukio
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依托单位:
X-Ray Crystal Structure Analysis of Recombinant Interleukin-2 and beta-Interferon
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批准号:62490005
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资助金额:$4.03万
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财政年份:1987
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负责人:MITSUI Yukio
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依托单位:
Elucidation of the Mechanisms of Induced-fit Movement imposed on Enzymes and Substrates as studied by Precise Crystal Structure Analysis.
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批准号:60580128
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.83万
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财政年份:1985
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负责人:MITSUI Yukio
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依托单位:
海外基金