Studies on Risk Factors of Stomach Cancer and Lung Cancer in People's Republic of China

中华人民共和国胃癌和肺癌危险因素研究

• 批准号: 02042002
• 负责人: SASAKI Ryuichiro
• 金额: $ 2.56万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02042002/
• 关键词: Stomach cancer; Lung cancer; Case-control study

In spite of big efforts of many researchers in the world, the causes of cancer and the mechanism of carcinogenesis have not been solved completely. The changing feachers in cancer with the passage of time may play some role these delay of the solution. It is one of the basic methods in epidemiologic research for getting the causes of a disease to do a comparative studies both in endemic area and in not endemic area of the disease. In the northern-east part of People Republic of China shows and interesting feature of the cancer occurrence, i. e. the frequency of stomach cancer is high in rural area and that of lung cancer in urbern area. These peculiar characteristics provide us for good field of cancer epidemiology.To solve some remained questions of stomach cancer and lung cencer, two case-control studies were conducted in this area ; one is for lung cancer in urbern area and the other for stomach cancer in rural area. Main results from these two studies are followed ;To clarify the c … More ausative factors to stomach cancer in high incidence area of stomach cancer, 288 newly diagnosed stomach cancer patients (266 males and 62 females) in rural area in Liaoning Province, China, were compared with those of age and sex matched 576 healthy controls. Patients with stomach cancer showed some typincal psychological features such as eating with angrily feeling (RR=3.39), irritable (RR=2.13), cheerful (RR=0.62), excitable (RR=1.80) and cold-hearted (RR=1.47). These results sugested that osycological factors might play some important roles in carcinogenesis of stomach cancer.To clarify the risk factors to lung cancer by histological types in Shenyang city, high incidence area of lung cancer, 100 newly diagnosed female lung cancer patients, were compared with those of age and sex matched 200 healthy controls. Smoking is the most causative factor (RR=2.1) for lung cancer as already showed in study in other area in the world. Lung cancer patients with squamous cell-carcinoma showed stronger relation to smoking habits (RR=2.9) than the other types of lung cancer patients. Less

尽管世界上许多研究人员付出了巨大的努力，但癌症的病因和致癌机制仍然没有完全解决。随着时间的推移，癌症中的变化因素可能在这些延迟解决中起一定作用。流行区与非流行区的比较研究是流行病学研究的基本方法之一。在中国东北地区，癌症的发生呈现出一个有趣的特点，即：e.胃癌高发于农村地区，肺癌高发于城市地区。为解决胃癌与肺癌的一些遗留问题，在本地区进行了两个病例对照研究，一个是城市肺癌，另一个是农村胃癌。这两项研究的主要结果如下： ...更多信息 为探讨胃癌高发区胃癌的危险因素，对辽宁省农村地区288例（男266例，女62例）新诊断胃癌患者和576例年龄、性别匹配的健康对照者进行了比较。胃癌患者具有典型的进食愤怒（RR=3.39）、易激惹（RR=2.13）、愉快（RR=0.62）、易激动（RR=1.80）、冷漠（RR=1.47）等心理特征。为明确胃癌的组织学类型与肺癌的危险因素，对沈阳市肺癌高发区100例新诊断的女性肺癌患者和200例年龄、性别相匹配的健康对照者进行了比较。吸烟是肺癌的主要致病因素（RR=2.1），这已在世界其他地区的研究中得到证实。肺癌伴鳞状细胞癌与吸烟习惯的相关性（RR=2.9）高于其他类型肺癌。少

项目成果

林 恵芝 他: "胃癌高率区居民血清学検査劫〓観察及基与低率区者対北" 中国医科大学学報. 19. 37-39 (1990)

Keizhi Hayashi等：“胃癌高发地区居民的血清学检查——低发地区居民与北方的观察与比较”，中国医科大学学报19. 37-39（1990）。

Bai Xi-Wen: "Gastroscopical findings of gastric mucosa in the volunteers at Zhuanghe and Vinmin counties with high and low incidence of gastric cancer" Journal of China Medical University. 19. 40-42 (1990)

白希文：“胃癌高发县和低发县志愿者胃黏膜胃镜检查结果”，中国医科大学学报。

Yoshinori Ito et al.: "Serum concentrations of carotenoids,retinol,and αーtocopherol in healthy persons determined by highーperformance liquid chromatography" Cliniaca Chimica Acta. 194. 131-144 (1990)

Yoshinori Ito 等人：“通过高效液相色谱法测定健康人中类胡萝卜素、视黄醇和 α-生育酚的血清浓度”Cliniaca Chimica Acta 194. 131-144 (1990)

Ryuichiro Sasaki et al.: "The relationship between serum betaーcarotene level and intake frequency of greenーyellow vegetables and some other factors" Epidemiology & Prevention of Cancer. 156-162 (1990)

Ryuichiro Sasaki 等人：“血清 β-胡萝卜素水平与绿黄色蔬菜摄入频率和其他一些因素之间的关系”流行病学与癌症预防 156-162 (1990)。

Ito, Yoshinori: "Serum concentrations of carotenoids, retinol, and alpha-tocopherol in healthy persons determined by high-performance liquid chromatography" Chimica Acta. 194. 131-144 (1990)

Ito，Yoshinori：“通过高效液相色谱测定健康人中类胡萝卜素、视黄醇和 α-生育酚的血清浓度”Chimica Acta。