Studies on Risk Factors of Stomach Cancer and Lung Cancer in People's Republic of China

尽管世界上许多研究人员做出了巨大努力，但癌症的病因和致癌机制仍未完全解决。随着时间的推移，癌症的变化因素可能会起到一定的作用，这些延缓了解决。对病区和非病区进行比较研究，是流行病学研究中确定病因的基本方法之一。我国东北地区的中国地区癌症的发生呈现出明显的特点，即胃癌高发于农村，肺癌高发于城市。为了解决胃癌和肺癌的一些遗留问题，在该地区开展了两项病例对照研究，一项是针对城市地区的肺癌，另一项是针对农村地区的胃癌。以下是这两个研究的主要结果；为了澄清c…在胃癌高发区，对辽宁省农村新诊断的288例胃癌患者中国(男266例，女62例)与年龄、性别相匹配的576例健康对照进行了比较。胃癌患者具有典型的进食心理特征，如愤怒(RR=3.39)、易怒(RR=2.13)、快乐(RR=0.62)、兴奋(RR=1.80)、冷酷(RR=1.47)。为明确肺癌高发区沈阳市肺癌的危险因素，对100例新诊断的女性肺癌患者与200例年龄、性别相匹配的健康对照进行比较。吸烟是肺癌的最主要致病因素(RR=2.1)，世界其他地区的研究已经表明这一点。与其他类型肺癌相比，肺癌合并鳞癌患者与吸烟习惯的相关性更强(RR=2.9)。较少

In spite of big efforts of many researchers in the world, the causes of cancer and the mechanism of carcinogenesis have not been solved completely. The changing feachers in cancer with the passage of time may play some role these delay of the solution. It is one of the basic methods in epidemiologic research for getting the causes of a disease to do a comparative studies both in endemic area and in not endemic area of the disease. In the northern-east part of People Republic of China shows and interesting feature of the cancer occurrence, i. e. the frequency of stomach cancer is high in rural area and that of lung cancer in urbern area. These peculiar characteristics provide us for good field of cancer epidemiology.To solve some remained questions of stomach cancer and lung cencer, two case-control studies were conducted in this area ; one is for lung cancer in urbern area and the other for stomach cancer in rural area. Main results from these two studies are followed ;To clarify the c … More ausative factors to stomach cancer in high incidence area of stomach cancer, 288 newly diagnosed stomach cancer patients (266 males and 62 females) in rural area in Liaoning Province, China, were compared with those of age and sex matched 576 healthy controls. Patients with stomach cancer showed some typincal psychological features such as eating with angrily feeling (RR=3.39), irritable (RR=2.13), cheerful (RR=0.62), excitable (RR=1.80) and cold-hearted (RR=1.47). These results sugested that osycological factors might play some important roles in carcinogenesis of stomach cancer.To clarify the risk factors to lung cancer by histological types in Shenyang city, high incidence area of lung cancer, 100 newly diagnosed female lung cancer patients, were compared with those of age and sex matched 200 healthy controls. Smoking is the most causative factor (RR=2.1) for lung cancer as already showed in study in other area in the world. Lung cancer patients with squamous cell-carcinoma showed stronger relation to smoking habits (RR=2.9) than the other types of lung cancer patients. Less