Nested case-control study to clarify a preventive factor of lung cancer.

巢式病例对照研究阐明肺癌的预防因素。

• 批准号: 20890291
• 负责人: SHIMAZU Taichi
• 金额: $ 2.11万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890291/
• 关键词: 肺癌; イソフラボン; 疫学; コホート研究; 癌

1) We investigated the association between isoflavone intake and lung cancer risk in a prospective cohort study. Isoflavone intake may be associated with a decreased risk of lung cancer in never smokers only. 2) We conducted a nested case-control study among women within the cohort, and found an inverse association between plasma level of genistein and lung cancer risk. The associations of isoflavone assessed by different methods with a decreased risk of lung cancer support the possibility that isoflavone is a preventive factor of lung cancer.

1)我们在一项前瞻性队列研究中调查了异黄酮摄入量与肺癌风险之间的关系。异黄酮的摄入可能只与从不吸烟的人患肺癌的风险降低有关。2)我们对队列内的女性进行了巢式病例对照研究，发现血浆染料木素水平与肺癌风险呈负相关。不同方法评估的异黄酮与降低肺癌风险的关系支持异黄酮是肺癌预防因素的可能性。

项目成果

ホームページ等。

主页等

Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan

• DOI: 10.3945/ajcn.2009.28161
• 发表时间: 2010-03-01
• 期刊: AMERICAN JOURNAL OF CLINICAL NUTRITION
• 影响因子: 7.1
• 作者: Shimazu, Taichi;Inoue, Manami;Tsugane, Shoichiro
• 通讯作者: Tsugane, Shoichiro