Epidemiologic Study on Risk Factors of Breast Cancer in South India

为明确印度南部马德拉斯地区素食者乳腺癌的发病关系，在1992~1993年的两年间进行了一项病例对照研究。通过对200例乳腺癌患者、200例年龄匹配的医院对照组(其他类型癌症患者)和200例健康对照组的资料分析，提出乳腺癌患者的以下特点：(1)乳腺癌患者经历了比医院和健康对照组更多的应激生活事件：(2)乳腺癌患者血清雌激素水平高于医院对照组。ELA试剂盒检测乳腺癌患者血清C-erb-B2蛋白阳性率为28.4%。(4)健康印度人血清β-胡萝卜素水平低于健康日本人。

To clarify the occurrence relation of breast cancer of vegetarians of Madras in southern India, between two years of 1992 to 1993 a case-control study was conducted. From the analyzes of information from 200 cases, and age matched 200 hospital controls (other types of cancer patients) and 200 healthy controls, following characteristics of breast cancer cases were suggested :(1) Breast cancer cases had experienced more stressful life events than both hospital and healthy controls.(2) Breast cancer cases showed higher serum levels of estrogen E1 than hospital controls. There were no significant difference of serum levels of estrogen E2 and E3 between cases and hospital controls.(3) The positive rate of C-erb-B2 protein using the ElA Kit (Trion Diagnostics AC-Alameda Ca) in serum of breast cancer cases was 28.4%.(4) Healthy Indians showed lower levels of serum beta-carotene than healthy Japanese.