Epidemiologic Study on Risk Factors of Breast Cancer in South India

印度南部乳腺癌危险因素的流行病学研究

• 批准号: 04042014
• 负责人: SASAKI Ryuichiro
• 金额: $ 6.4万
• 依托单位: Aichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04042014/
• 关键词: Breast cancer; Case-control study; India; Hormone; Beta-carotene; Epidemiology; β-カロチン

To clarify the occurrence relation of breast cancer of vegetarians of Madras in southern India, between two years of 1992 to 1993 a case-control study was conducted. From the analyzes of information from 200 cases, and age matched 200 hospital controls (other types of cancer patients) and 200 healthy controls, following characteristics of breast cancer cases were suggested :(1) Breast cancer cases had experienced more stressful life events than both hospital and healthy controls.(2) Breast cancer cases showed higher serum levels of estrogen E1 than hospital controls. There were no significant difference of serum levels of estrogen E2 and E3 between cases and hospital controls.(3) The positive rate of C-erb-B2 protein using the ElA Kit (Trion Diagnostics AC-Alameda Ca) in serum of breast cancer cases was 28.4%.(4) Healthy Indians showed lower levels of serum beta-carotene than healthy Japanese.

为了弄清印度南部马德拉斯地区素食者乳腺癌的发生关系，1992 - 1993年进行了一项病例对照研究。通过对200例病例的信息分析，以及年龄匹配的200例医院对照（其他类型的癌症患者）和200例健康对照，得出乳腺癌病例的以下特征：(1)乳腺癌患者比医院对照和健康对照经历了更多的生活压力事件。(2)乳腺癌患者血清雌激素E1水平高于医院对照组。患者血清雌激素E2和E3水平与医院对照无显著差异。(3)应用ElA试剂盒（Trion Diagnostics AC-Alameda Ca）检测乳腺癌患者血清c - erbb - b2蛋白的阳性率为28.4%。(4)健康印度人的血清β -胡萝卜素水平低于健康日本人。

项目成果

Hiroshi Ogawa: Shinohara-Shuppan. Gan-no-Minzokuekigaku, 1-214 (1993)

小川浩：筱原Shuppan。

伊藤 宜則,佐々木 隆一郎: "ベータ-カロチンとがん予防" 食品工業. 36. 28-48 (1992)

伊藤义典 (Yoshinori Ito)、佐佐木龙一郎 (Ryuichiro Sasaki)：“β-胡萝卜素与癌症预防”食品工业。 36. 28-48 (1992)

小川 浩: "がんの民族疫学(田島和雄編)「がんの記述疫学:世界と日本の分布特性とその背景要因」" 篠原出版, 1-214 (1993)

小川宏：“癌症的种族流行病学（田岛和夫编辑）‘癌症的描述性流行病学：世界和日本的分布特征和背景因素’”筱原出版社，1-214（1993）

伊藤 宜則、佐々木 隆一郎: "ベータ-カロチンとがん予防" 食品工業. 36. 28-48 (1993)

伊藤义德 (Yoshinori Ito)、佐佐木龙一郎 (Ryuichiro Sasaki)：“β-胡萝卜素与癌症预防”食品工业 36. 28-48 (1993)。