Evaluation of liver graft viability in human liver transplantation.

人肝移植中肝移植物活力的评估。

• 批准号: 02044086
• 负责人: OZAWA Kazue
• 金额: $ 7.04万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02044086/
• 关键词: Liver Transplantation; Initial Non-Functioning Liver; Viability of The Liver Graft; Arterial Ketone Body Ratio; 血中ケトン体比

Viability of the donor liver was assessed with regard to the early postoperative survival in human liver transplantations from 40 brain-dead donors in Hannox-er Medical College (MHH) and 31 living donors in Kyoto University (KYOTO) by measuring arterial ketone body ratio (AKBR). Of 40 cases harvested from brain-dead patients in MHH, 35 cases survived the first week after operation, but 5 cases developed the initial nonfunction of the transplanted graft (INF) and died within the first week. The mean valued of AKBR of each group were 1.10<minus-plus>0.10 and 0.44<minus-plus>0.10, respectively (p<0.01). A-I (BR of the 5 INF cases were all below 0.7. Of 31 cases harvested from the living donors in KYOTO, all survived the first week, and AKBR values of them were almost above 1.0 with the mean value of 1.85<minus-plus>0.23. In total of 66 cases, survival rates of the cases whose AKBR were higher than 0.7 was significantly higher than that of the cases whose AKBR were below 0.7 (100% v. s. 42%, p<It is demonstrated that AKBR can be the effective scientific scale to evaluate the viability of the donor liver.

通过测量动脉酮体比率 (AKBR)，对汉诺克斯医学院 (MHH) 的 40 名脑死亡供者和京都大学 (KYOTO) 的 31 名活体供者进行的人类肝移植术后早期存活率评估了供肝的活力。 MHH 采集的 40 例脑死亡患者中，35 例在术后第一周存活，但 5 例出现移植物最初无功能（INF）并在第一周内死亡。每组的AKBR平均值分别为1.10<减-加>0.10和0.44<减-加>0.10(p<0.01)。 A-I（5例INF病例BR均低于0.7。京都活体供体采集的31例中，第一周均存活，AKBR值几乎在1.0以上，平均值为1.85<负加>0.23。总共66例中，AKBR高于0.7的病例存活率明显高于AKBR低于的病例0.7（100% 对比 42%，p<证明AKBR可以作为评价供肝活力的有效科学量表。

项目成果

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A.Tanaka 等人：“增强线粒体磷酸化在大鼠肝移植中的作用。”

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K. Ozawa 等人：“动脉血中的乙酰乙酸/B-羟基丁酸与冷冻捕获的人肝组织中的氧化黄素蛋白/还原吡啶核苷酸之间的线性相关性。”

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K.Ozawa,et al.: "Experience with 225 hepatic resections for hepatocellular carcinoma over a 4-year period." Am.J.Surg.,. 161. 677-682 (1991)

K.Ozawa 等人：“4 年期间进行 225 例肝细胞癌肝切除术的经验。”

A. Tanaka, et al.: "The role of enhanced mitochondrial phosphorylation in rat liver transplantation." J. Surg. Res.

A. Tanaka 等人：“增强线粒体磷酸化在大鼠肝移植中的作用。”