Use of Redox theory in the perioperative metabolic support and the treatment in liver surgery and transplant.

氧化还原理论在肝脏手术和移植围手术期代谢支持和治疗中的应用。

• 批准号: 02404053
• 负责人: OZAWA Kazue
• 金额: $ 18.88万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404053/
• 关键词: Redox Theory; Liver Transplantation; Donor Liver Viability; AKBR; Living Relared Partial Liver Transplantation; Hepatic Surgery; ex situ; 甲状腺ホルモン; 肝移植術; 代謝管理

As a result of the international cooperative study with the transplantation centers in advanced countries, Redox theory has been proven to be useful in the field of liver transplantation. In the preoperative stage, estimation of donor liver viability before procurement has been performed by means of arterial ketone body ratio (AKBR), and the higher is the valve of AKBR, the more viable is the donor liver. In the operative stage, operative stress has been measured by means of AKBR, and operative techniques have been refined to minimize the stress. In the postoperative stage, AKBR can be the indicator of early graft survival and inadequate recovery of AKBR after operation means the inadequate function of the transplanted graft, and retransplant should be performed. All these results were integrated in the living related partial liver transplantations, which are performed in our department, and 29 cases have already been operated successfully since June, 1990.Thus, in both fields of hepatic surgery and liver transplantaion, Redox theory is widely applied and successful results have been made.

通过与先进国家移植中心的国际合作研究，氧化还原理论在肝移植领域已被证明是有用的。术前阶段，通过动脉酮体比值（AKBR）来评估供肝的存活率，AKBR值越高，供肝的存活率越高。在手术阶段，通过AKBR测量手术压力，并改进手术技术以尽量减少压力。术后阶段，AKBR可作为早期移植物成活的指标，术后AKBR恢复不充分则意味着移植物功能不足，应再次移植。这些成果均融入到我科开展的活体部分肝移植中，自1990年6月起已成功手术29例。由此，氧化还原理论在肝外科和肝移植领域得到广泛应用，并取得了成功的成果。

项目成果

Nobuhiro Ozaki: "Ketone body ratio as an indicator of early graft survival in clinical liver transplantation." Clin.Transplantation.

Nobuhiro Ozaki：“酮体比作为临床肝移植​​中早期移植物存活的指标。”

N.Ozaki,et al.: "Ketone body ratio as an indicator of early graft survival in clinical liver transplantation." Clin.Transplantation,. 5. 48-54 (1991)

N.Ozaki 等人：“酮体比作为临床肝移植​​中早期移植物存活的指标。”

KATSUHIRO, ASONUMA: "The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation." Transplantation. 51. 164-171 (1991)

KATSUHIRO, ASONUMA：“动脉酮体比率作为人体肝移植中移植物活力的早期指标的临床意义。”

D.Manaka,et al.: "Hemodynamic stability and metabolic preservation of the liver under simultaneous administration of vasopressin and epinephrine in brainーdead dogs." Transplantation. 49. 1188-1190 (1990)

D. Manaka 等人：“脑死亡狗同时施用加压素和肾上腺素时肝脏的血流动力学稳定性和代谢保存。” 49. 1188-1190 (1990)。

D.Manaka,et al.: "Hemodynamic stability and metabolic preservation of the liver under simultaneous administration of vasopressin and epinephrine in brain-dead dogs." Transplantation. 49. 1188-1190 (1990)

D.Manaka 等人：“同时给予脑死亡狗加压素和肾上腺素时肝脏的血流动力学稳定性和代谢保存。”