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Studies of the Etiology and Therapeutic Approach of Alveolar Bone Resorption

牙槽骨吸收的病因及治疗方法研究

基本信息

批准号：
02304050
负责人：
OGURA Hideaki
金额：
$ 13.38万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

The following main results were obtained in the present joint study. I. Research Group of Experimental Animal Model of Bone Resorption: 1) During the phase of bone resorption in the bone marrow cavity of rat by an injection of colchicine, osteopontin mRNA expression was observed. 2) Lathyrogenic agents induced a severe resorption of the area of alveolar bone and periodontium in rat. This alveolar bone resorption may be a new model of experimental alveolar bone resorption. II. Research Group of the Function Producing Mechanism in Bone Resorption: 1) The presence of the monouclear osteoclast was ascertained and the three-dimensional structure of locomoting osteoclast was clarified. 2) The lack of bone resorption in op/op mice is due to the inability of the local microenvironment production by osteoblastic cells. In contract, the lack of bone resorption in oc/oc mice is due to a defect in osteoclast progenitors. 3) It was found that osteoclast formation required some unknown factor(s) pro … More duced by stromal cells through PGE_2 and protein A kinase pathway and that the osteoclast formation also required direct adherence of stromal cells to stem cells through some cell adhesion molecules such as ICAM-1 and LFA-1.4) Several kinds of cytokines produced by squamous cell carcinoma are responsible to a marked increase in osteoclastic bone resorption and malignancy associated hypercalcemia. 5) S180A, an animal model of malignancy, produced bone resorbing factors such as TGFalpha and IL-1alpha. III. Research Group of the Prevention and Therapeutic Approach to Alveolar Bone Resorption: 1) The circadian phase of bone resorption is an important factor controlling the magnitude in the effect of blockers of bone resorption. 2) The increased levels of osteocalcin in gingival crevicular fluid may reflect the severity of periodontal tissue breakdown. 3) The bone morphogenetic protein-atelocollagen complex induced the new bone formation in rat. 4) The occluding load of the lower denture during mastication may be an effecting factor on the alveolar bone resorption. 5) Aspirin may have an inhibitory effect on alveolar bone resorption in the mandible with traumatic occlusion. Less

本联合研究取得了以下主要成果。I.骨吸收实验动物模型研究组：1）在大鼠骨髓腔注射秋水仙碱后骨吸收阶段，观察骨桥蛋白mRNA的表达。2)致甲状腺激素可引起大鼠牙槽骨和牙周组织严重吸收。这种牙槽骨吸收可能是一种新的实验性牙槽骨吸收模型。二.骨吸收功能产生机制研究组：1）确定了单核破骨细胞的存在，阐明了单核破骨细胞的三维结构。2)OP/OP小鼠中骨吸收的缺乏是由于成骨细胞不能产生局部微环境。相反，oc/oc小鼠缺乏骨吸收是由于破骨细胞祖细胞的缺陷。3)发现破骨细胞的形成需要一些未知的因子促进， ...更多信息破骨细胞的形成还需要基质细胞通过细胞粘附分子ICAM-1和LFA-1与干细胞直接粘附。4）鳞状细胞癌产生的多种细胞因子是导致骨吸收明显增加和恶性肿瘤相关高钙血症的原因。5)S180 A是一种恶性肿瘤动物模型，产生了骨吸收因子，如TGF α和IL-1 α。三.牙槽骨吸收防治研究课题组：1）骨吸收的昼夜节律是控制骨吸收阻滞剂作用大小的重要因素。2)龈沟液中骨钙素水平的升高可能反映了牙周组织破坏的严重程度。3)骨形态发生蛋白-去端胶原复合物诱导大鼠新骨形成。4)下颌义齿咀嚼时的咬合负荷可能是影响牙槽骨吸收的一个因素。5)阿司匹林可能对创伤性咬合的下颌骨牙槽骨吸收有抑制作用。少