Effect of Gastrointestinal Hormones on Organ Interrelationship

胃肠激素对器官相互关系的影响

• 批准号: 02404052
• 负责人: INOUE Kazutomo
• 金额: $ 12.42万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404052/
• 关键词: EGF & Pancreatic regeneration; GIP & splanchnic circulation; Endothelin & pancreas; Post-gastrectomy gallstone; FK506 and cyclosporine; Isolation of islet from adult pit pancreas; Hybrid islet pancreas with MRPT; Transplantation; GIP; 成熟ブタ膵ラ氏島

1. Clarification of involvement of EGF in the mechanism of pancreatic regeneration after pancreatectomy in adults rats2. Observation on the increased effect of GIP on the intestinal and liver blood flows in conscious dogs3. Observation on the decreased effect of Endothelin on the mocrocirculation of the pancreas4. Clarification of the mechanism of post-gastrectomy gallbladder sludge and stone in relation to gastrointestinal hormones and gallbladder contracfile function5. Clarification of the effect of FK506 and cyclosporine on exocrine pancreatic secretion and various immunological parameters6. New development of isolation procedure for islets from adult pig pancreas7. Assessment of viability of isolated adult pig islets both in vitro study and in vivo xinotransplantation study with FK506 and DSG8. Study on the hybrid islet pancreas with mesh-reinforced polyvinyl alcohol tube (MRPT) ; Evaluation of this new type of artificial pancreas as a promising therapeutic approach to diabetes mellitus both in Vitro and in vivo transplantation study

1.阐明EGF在成年大鼠胰腺切除后再生机制中的作用GIP对清醒犬肠道和肝脏血流增加作用的观察内皮素对胰腺微循环影响的观察4。阐明胃切除术后胆汁和结石与胃肠激素和胆汁收缩功能的关系。阐明FK506和环孢素对胰腺外分泌和各种免疫学参数的影响。成年猪胰岛分离方法的新进展7。应用FK506和DSG8对分离的成年猪胰岛进行体外和体内异体移植的活性评估。网状增强聚乙烯醇管(MRPT)复合胰岛的研究这种新型人工胰腺作为一种有前途的治疗糖尿病的方法的体内外移植研究

项目成果

Inoue,K.: "Isolation of adult pig islet:In vitro assessment and xenotransplantation" Int.J.Pancreat.

Inoue,K.：“成年猪胰岛的分离：体外评估和异种移植”Int.J.Pancreat。

Doi,R.: "Measurement of splanchnic circulation in dogs;changes induced by prostaglandin E" Scand J.Gastroenterol.25. 951-956 (1990)

Doi,R.：“狗内脏循环的测量；前列腺素 E 引起的变化”Scand J.Gastroenterol.25。

Inoue K.: "Changes in cholecystokinin release and gallbladder function in gastrectomized patients-follow up study-" Life Sci.Adv.10. 19-22 (1991)

Inoue K.：“胃切除患者胆囊收缩素释放和胆囊功能的变化 - 后续研究 -”Life Sci.Adv.10。

Inoue,K.: "Experimental hybrid islet transplantation:Application of polyvinyl alcohol membrane for entrapment of islets" Pancreas.

Inoue,K.：“实验性混合胰岛移植：应用聚乙烯醇膜捕获胰岛”胰腺。

Inoue K: "Changes in cholecystokinin release and gallbladder function in gastrectomized patients - follow up study -" Life Sci. Adv.10. 19-22 (1991)

井上 K：“胃切除患者胆囊收缩素释放和胆囊功能的变化 - 随访研究 -”《生命科学》。