An Open Source Approach to Understanding an Important Parasite Ion Pump

了解重要寄生离子泵的开源方法

• 批准号: LP150101226
• 负责人: Prof Peter Rutledge
• 金额: $ 28.52万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-12-03 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150101226
• 关键词: Open; Source; Approach; Understanding; Important

This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membrane biology, and by leveraging global scientific inputs through online research methods allowing anyone to participate.

该项目计划合成新的化合物，结合蛋白质ATP 4，这是疟疾寄生虫中必不可少的离子泵。它计划生成一个三维地图，以了解这些化合物如何阻止ATP 4工作。几种有希望的疟疾新药靶向ATP 4，但我们不清楚它们是如何做到的。该项目的预期目标将使用合成化学和膜生物学的新方法，并通过允许任何人参与的在线研究方法利用全球科学投入来实现。