Myocardial anisotropy and cardiac arrhythmias

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The effects of acute ischemia on conduction velocites in the longitudinal (VL) and transverse (VT) fiber axis were determined from epicardial activation patterns, recorded with 48 bipolar electrodes on the left anterior and posterior canine ventricular wall. During the control state VL was greater than VT demonstrating anisotropic properties of cardiac muscle. During acute ischemia VL and VT were decreased from the control value and VT was decreased greater extent than VL resulting in an increase in VL/T in both anterior and posterior wall. This augumented anisotropic ventricular conduction may have some relation to the initiation of ventricular arrhythmias during acute ischemia.