Growth of an electric stimulated perichondrium

电刺激软骨膜的生长

• 批准号: 02807115
• 负责人: TAKAHASHI Hajime
• 金额: $ 1.02万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807115/
• 关键词: Perichondrium; Electrostimulation; Microtia

Auricular deformity occurs from cartilages deformities and hypoplasia. Microtia is a severe auricle deformity and it is said l microtia patient per 20,000 births in Japan. My purpose for this research is the establishment of the microtia reconstruction method using perichondrium of the costal cartilage. Because of only perichondrium removal, no costal deformity occurs.In point of view, I would like to do research about fundamental reaction of transplanting perichondrium. To create the shape of an Auricle; I like to use "Shape Memory Alloys". I removed perichondrium from a rabbit's ear. Then the perichondrium is wrapped around the shape Memory Alloy and placed subcutaneously into the rabbit's back.Grafted perichondrium will be removed from the back in 1, 2, 3 and 6 months later for examination by soft X-ray. I will check the tissue adaptation between Shape Memory Alloy and electrically stimulated perichondrium. I will also start long term observations for periods greater than 12 months.I am now doing very fundamental observations of having put in the standard (uncovered) Shape Memory Alloy, subcutaneously. I would like to continue this research for a few more years.

耳廓畸形源于软骨畸形和发育不全。小耳畸形是一种严重的耳廓畸形，据说日本每2万名新生儿中就有1名小耳畸形患者。我的研究目的是建立利用肋软骨软骨膜重建小体的方法。由于只切除硬骨膜，没有发生肋部畸形。有鉴于此，我想对软骨膜移植的基本反应进行研究。形成耳廓的形状；我喜欢用“形状记忆合金”我从兔子耳朵里取出了软骨膜。然后将软骨膜包裹在形状记忆合金上，并皮下植入兔子的背部。1、2、3、6个月后将移植的软骨膜从背部取出，进行软x线检查。我会检查形状记忆合金和电刺激软骨膜之间的组织适应性。我也将开始为期12个月以上的长期观察。我现在正在做非常基本的观察，把标准的（未覆盖的）形状记忆合金放入皮下。我想继续这项研究几年。