NMR machine, 600 MHz

核磁共振机，600 MHz

• 批准号: 523962002
• 金额: --
• 依托单位: Humboldt-Universität zu Berlin
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/523962002?language=en
• 关键词: NMR; machine; 600; MHz

The department of chemistry of the Humboldt Universität zu Berlin requires a high-frequency 600 MHz NMR device to carry out its research. The new machine will be a replacement for a very well utilised device that was commissioned in 1993. The console was replaced in 2005 and repairs by the manufacturer can no longer be guaranteed. Due to the age of the magnet, a connection to the helium recovery system has not been possible so far, i.e. a new unit would also save running costs considerably. In addition, the magnet cannot be cooled below -10°C due to its fragility. The personnel as well as the experience and competence for high-field NMR spectroscopy are existing. The device is needed by a number of research groups whose research work requires NMR measurements with high resolution and sensitivity. The device will also be used by the specified research groups within the framework of research networks. In the field of bioorganic chemistry, protein domains and nucleic acid strands are investigated. Accordingly, the requirements for sensitivity and resolution of the measurements in this area are very high. Furthermore, many of the systems to be studied exhibit a dynamic behavior on the NMR time scale, the investigation of which also requires a high-frequency device. Among them are metal complexes as well as supramolecular compounds. A 3-channel device is crucial for the planned measurements. In the field of inorganic chemistry, correlation and decoupling experiments must be carried out due to the high bandwidth of nuclei to be measured, which often require three channels. Especially in the field of low-gamma nuclei (e.g. for 103Rh), sensitivity plays a crucial role, even when applying magnetisation transfer from more sensitive nuclei such as 1H, 19F or 31P. For the measurement of common triple resonance experiments of protein domains as well as nucleic acids, a 3-channel spectrometer is also mandatory.

柏林洪堡大学化学系需要一台高频600 MHz NMR设备来进行研究。这台新机器将取代1993年投入使用的一台使用率很高的设备。该控制台在2005年被更换，制造商的维修不再得到保证。由于磁体的老化，到目前为止还不可能连接到氦回收系统，即新的装置也可以大大节省运行成本。此外，由于其易碎性，磁体不能冷却到-10 ° C以下。高场核磁共振光谱学的人员以及经验和能力是现有的。许多研究小组需要该设备，这些研究小组的研究工作需要高分辨率和高灵敏度的NMR测量。该设备还将在研究网络框架内由指定的研究小组使用。在生物有机化学领域，研究蛋白质结构域和核酸链。因此，在该领域中对测量的灵敏度和分辨率的要求非常高。此外，许多待研究的系统在NMR时间尺度上表现出动态行为，其研究也需要高频设备。其中包括金属配合物以及超分子化合物。3通道设备对于计划的测量至关重要。在无机化学领域，由于被测原子核的带宽很高，必须进行相关和退耦实验，这往往需要三个通道。特别是在低伽马核（例如103 Rh）领域，灵敏度起着至关重要的作用，即使在应用来自更灵敏的核（例如1H、19 F或31 P）的磁化转移时也是如此。对于蛋白质结构域以及核酸的常见三重共振实验的测量，3通道光谱仪也是强制性的。