DEVELOPMENT OF MULTIPURPOSED PEDIATRIC BLOOD PUMP AND ITS DRIVING AND AUTOMATIC CONTROL MACHINE
DEVELOPMENT OF MULTIPURPOSED PEDIATRIC BLOOD PUMP AND ITS DRIVING AND AUTOMATIC CONTROL MACHINE
批准号:
02557053
负责人:
ITO Takahiro
金额:
$8.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
财政年份:
1990
资助国家:
日本
项目状态:
已结题
起止时间:
1990 至 1992
中文摘要
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英文摘要
A multipurposed pediatric blood pump and its driving and automatic control unit, which had been developed from an adult blood pump was miniaturized. Function, safety, and durability of the pump and the driving and control unit were tested on a mock circulation and on experimental animals. It was confirmed that the blood pump and the driving and control unit are capable to increase the output according to the venous return automatically, to keep the output against increasing resistance in the outflow tract, and to stop pumping when the outflow tract is suddenly obstructed.Our new ECMO circuit were used on 3 newborns with severe respiratory distress during the 3 year period. Although we could not success in saving lives of these infants, we confirmed that the system works satisfactorily. Experimentally we knew that high flow ECMO results in decrease in the coronary arterial flow. The liver was perfused successfully with the automatic blood pump system, which will be used for surgery, chemotherapy for inoperable malignancies of the liver. We are now developing a new blood pump using a tube shaped blood chamber made of polyurethan with a new photo-sensor and also a portable driving and control unit.
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Takagi H, et al.: "New artificial heart which operates on Starling's law." Artificial Organs. 14(Suppl.4). 49-51 (1991)
Takagi H 等人:“根据 Starling 定律运行的新型人造心脏。”
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通讯作者:
伊藤 喬廣: "小児の人工臓器" 医学のあゆみ. 160. 469-469 (1992)
Takahiro Ito:“儿童人工器官”医学史 160. 469-469 (1992)。
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ITO T,SEO T,et al.: "First clinical application of automatic VA-ECMO system using artificial hearts as a blood pump." J Pediatr Surg.
ITO T、SEO T 等人:“使用人造心脏作为血泵的自动 VA-ECMO 系统的首次临床应用。”
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瀬尾 孝彦、伊藤 喬廣他3名: "自動制御血液ポンプを用いた新生児小児用自動ECMO装置の開発と性能" 人工臓器. 21. 31-37 (1992)
Takahiko Seo、Takahiro Ito 和其他 3 人:“使用自动控制血泵的新生儿和儿童自动 ECMO 设备的开发和性能”Artificial Organs(人工器官)。
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SEO T,ITO T et al.: "Experimental study on the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation with an automatically driven blood pump on puppies." Artificial Organs. 15. 402-407 (1991)
SEO T、ITO T 等人:“利用自动驱动血泵对小狗进行静脉-动脉体外膜氧合的血流动力学影响的实验研究。”
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