DEVELOPMENT OF MULTIPURPOSED PEDIATRIC BLOOD PUMP AND ITS DRIVING AND AUTOMATIC CONTROL MACHINE

多功能小儿血泵及其驱动、自动控制机的研制

• 批准号: 02557053
• 负责人: ITO Takahiro
• 金额: $ 8.83万
• 依托单位: NAGOYA UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02557053/
• 关键词: BLOOD PUMP; AUTOMATIC CONTROL; EXTRACORPOREAL MEMBRANE OXYGENATION; ECMO; CONGENITAL DIAPHRAGMATIC HERNIA; NEONATAL RESPIRATORY DISTRESS; 先天性横隔ヘルニア; 自動制御駆動装置

A multipurposed pediatric blood pump and its driving and automatic control unit, which had been developed from an adult blood pump was miniaturized. Function, safety, and durability of the pump and the driving and control unit were tested on a mock circulation and on experimental animals. It was confirmed that the blood pump and the driving and control unit are capable to increase the output according to the venous return automatically, to keep the output against increasing resistance in the outflow tract, and to stop pumping when the outflow tract is suddenly obstructed.Our new ECMO circuit were used on 3 newborns with severe respiratory distress during the 3 year period. Although we could not success in saving lives of these infants, we confirmed that the system works satisfactorily. Experimentally we knew that high flow ECMO results in decrease in the coronary arterial flow. The liver was perfused successfully with the automatic blood pump system, which will be used for surgery, chemotherapy for inoperable malignancies of the liver. We are now developing a new blood pump using a tube shaped blood chamber made of polyurethan with a new photo-sensor and also a portable driving and control unit.

小的小儿血泵及其驾驶和自动控制单元是由成人血泵开发的。在模拟循环和实验动物上测试了泵的功能，安全性和耐用性以及驾驶和控制单元。有人证实，血泵以及驾驶和控制单元能够根据静脉回报自动增加输出，以保持输出，以防止流出道的耐药性增加，并在突然阻塞流出的ECMO电路时停止抽水。在3年内，我们的3个新生儿使用了新的ECMO电路。尽管我们无法成功地挽救这些婴儿的生命，但我们确认该系统令人满意地工作。在实验上，我们知道高流量ECMO会导致冠状动脉流量减少。通过自动血泵系统成功灌注肝脏，该系统将用于手术，化学疗法，用于无法手术的肝脏恶性肿瘤。现在，我们正在使用由聚氨酯制成的管形血液室开发新的血泵，并带有新的照相传感器以及便携式驾驶和控制单元。

项目成果

伊藤 喬廣: "小児の人工臓器" 医学のあゆみ. 160. 469-469 (1992)

Takahiro Ito：“儿童人工器官”医学史 160. 469-469 (1992)。

Takagi H, et al.: "New artificial heart which operates on Starling's law." Artificial Organs. 14(Suppl.4). 49-51 (1991)

Takagi H 等人：“根据 Starling 定律运行的新型人造心脏。”

ITO T,SEO T,et al.: "First clinical application of automatic VA-ECMO system using artificial hearts as a blood pump." J Pediatr Surg.

ITO T、SEO T 等人：“使用人造心脏作为血泵的自动 VA-ECMO 系统的首次临床应用。”

瀬尾 孝彦、伊藤 喬廣他3名: "自動制御血液ポンプを用いた新生児小児用自動ECMO装置の開発と性能" 人工臓器. 21. 31-37 (1992)

Takahiko Seo、Takahiro Ito 和其他 3 人：“使用自动控制血泵的新生儿和儿童自动 ECMO 设备的开发和性能”Artificial Organs（人工器官）。

SEO T,ITO T et al.: "Experimental study on the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation with an automatically driven blood pump on puppies." Artificial Organs. 15. 402-407 (1991)

SEO T、ITO T 等人：“利用自动驱动血泵对小狗进行静脉-动脉体外膜氧合的血流动力学影响的实验研究。”