Analysis of the ER molecular chaperone in inflammatory bowel disease.

点击翻译按钮获取中文摘要

The amount of HD5 and HD6 secreted from a single small bowel crypt was estimated. In Crohn's disease patients, the ileal expression of HD5 mRNA was significantly reduced compared with controls. Protein disulfide isomerase (PDI) was expressed in Paneth cells. This study suggested that it was important for disulfide bond formation of defensin. The Paneth cell secretions induced IL-8, TNF-α,IL-1β, IL-13, RANTES and TGF-β1 from T84 cells. Human Paneth cells contribute to innate as well as adaptive immunity by defensin-dependent and -independent processes, which appear to be mediated by induction of pro-inflammatory cytokines. A deficiency of the α-defensins derived from Paneth cells is considered to be associated with various gut diseases, including Crohn's disease.