Endocrine Therapy for Scirrhous-Type Gastric Cancer

硬质型胃癌的内分泌治疗

• 批准号: 02670584
• 负责人: KOJIMA Osamu
• 金额: $ 1.41万
• 依托单位: Kyoto Prefectural Universtiy of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670584/
• 关键词: Scirrhous type gastric cancer; Endocrine therapy for gastric cancer; Aromatase; Aromatase inhibitor; estrogen; estrogen receptor; Aromatase in gastric cancer; Aromatase in omentum; 胃癌組織内のエストロジェン・リセプシ-; 胃癌血液中のエストロジェン患者; 胃癌組織のアロマタ-ゼ; 胃癌組織内のエストロジェ

It is generally speaking that scirrhous type gastric cancer shows poor ptgnosis. We reported that some of gastric cancers were responded to endocrine therapy. In this study, it is examined whether new endocrinie therapy drug, aromatase inhibitor is effective for gastric cancer as breast cancer. In vitro-study, aromatase inhibitor (GGS. 16949A) inhibited gastric cancer proliferation as breast cancer cells. The activities of aromatase were high in gastric cancer tissues and omental tissues as in breast cancer tissues. After administration of aromatase inhibitors, the estrogen levels of gastric cancer decreased. These results suggest that aromatase inhibitors is useful for endocrine treatment of gastric cancer.

一般来说，硬质型胃癌的诊断率较差。我们报道了一些胃癌对内分泌治疗有反应。本研究旨在探讨新型内分泌治疗药物芳香酶抑制剂对胃癌是否与乳腺癌一样有效。体外研究中，芳香酶抑制剂（GGS.16949A）可抑制胃癌细胞和乳腺癌细胞的增殖。与乳腺癌组织一样，胃癌组织和大网膜组织中芳香酶活性较高。服用芳香酶抑制剂后，胃癌的雌激素水平下降。这些结果表明芳香酶抑制剂可用于胃癌的内分泌治疗。

项目成果

Osamu.Kojima et al.: "Localization of estrogen receptor in gastric cancer using immunohisto chemical staining of monoclonal antibody." Cancer. 67. 2401-2406 (1991)

Osamu.Kojima 等人：“使用单克隆抗体的免疫组织化学染色定位胃癌中的雌激素受体。”

M.Matsui,O.Kogima: "Characterijation of estrogen receptor in human gastric cancer" Cancer. 68. 305-308 (1991)

M.Matsui，O.Kogima：“人胃癌中雌激素受体的特征”癌症。

O. Kojima: "Relationship between gastric cancer and sex hormone." Karkinos. 4. 1011-1019 (1991)

O. Kojima：“胃癌与性激素之间的关系。”

M.Mtsui,O.Kogima: "Characterization of estrogen receptor in human gastric cancer" Cancer. 68. 305-308 (1991)

M.Mtsui，O.Kogima：“人类胃癌中雌激素受体的表征”癌症。

M. Matsui: "Characterization of estrogen receptor in human gastric cancer" Cancer. 68. 305-308 (1991)

M. Matsui：“人类胃癌中雌激素受体的表征”癌症。