THE EFFECTS OF STELLATE GANGLION BLOCK TOGETHER WITH OXYGEN.CARBON DIOXIDE OR PROSTAGLANDIN E1 ON CRANIAL CIRCULATION

星状神经节阻滞联合氧气、二氧化碳或前列腺素E1对颅循环的影响

• 批准号: 02670674
• 负责人: KANEKO Tadanobu
• 金额: $ 1.54万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670674/
• 关键词: Stellate ganglion block; Cerebral blood flow; Laser doppler flow meter; Oxygen; Carbon dioxide; Hypercapnia; Prostaglandin E1; Vertebral blood flow; 脳血流; プロマタグランジンE_1; 総頚動脈血流量; レーザードッブラー血流計; プロスタグランジンE_1; 炭酸ガス; 酸素; 脳循環障害

I studied the effects of left stellate ganglion block (LtSGB) used together with 5% CO2 inhalation or intravenous prostaglandin E1 (PGE1) for cerebral blood flow (CBF) in dogs. CBF was measured at the surface of cerebral cortex using disc-type-probe of laser doppler flow meter. LtSGB didn't change blood pressure, heart rate and cardiac output.LtSGB significantly increased left common carotid blood flow (Ca-BF) and left vertebral blood flow (VBF), but decreased CBF in SGB side. Inhalation of 5% CO2 induced hypercapnia (PaCO2:50mmHg) and increased CBF. These findings suggest that SGB increase external carotid blood flow in SGB side, but not internal carotid blood flow, therefore CO2 inhalation is effective for disturbance of CBF rather than SGB.The dose of 200ng/kg/min of PGE1 increased Ca-BF and VBF as much as approximately 10% by its direct vasodilative action, but didn't change CBF. After SGB, the effect of PGE1 was augumented clearly at the rate of increase of Ca-BF and VBF in SGB side.These findings suggest PGE1 has vasodilative effects for external carotid artery and vertebral artery as well as SGB,and remarkable synergic effects related to the sympathetic ganglion block. So, SGB using together with PGE1 is more effective for blood insufficiency of the region of external carotid artery and vertebral artery.

我研究了左星状神经节阻滞 (LtSGB) 与 5% CO2 吸入或静脉注射前列腺素 E1 (PGE1) 一起使用对狗脑血流量 (CBF) 的影响。使用激光多普勒流量计盘式探头在大脑皮层表面测量CBF。 LtSGB不改变血压、心率和心输出量。LtSGB显着增加左颈总动脉血流量(Ca-BF)和左椎血流量(VBF)，但降低SGB侧CBF。吸入5%CO2引起高碳酸血症（PaCO2：50mmHg）并增加CBF。这些结果表明，SGB增加了SGB侧的颈外动脉血流量，但不增加颈内动脉血流量，因此吸入CO2对CBF的干扰比SGB更有效。200ng/kg/min的PGE1剂量通过其直接的血管舒张作用使Ca-BF和VBF增加约10%，但不改变CBF。 SGB后，PGE1的作用随着SGB侧Ca-BF和VBF的增加而明显增强。这些结果表明PGE1对颈外动脉和椎动脉以及SGB具有血管舒张作用，并且与交感神经节阻滞相关的显着协同作用。因此，SGB与PGE1联合使用对于颈外动脉和椎动脉区域的血供不足更为有效。

项目成果

徳富 昭一郎: "プロスグランジンE_1投下の臓器機能に及ぼす影響" 現代医療. 23. 2815-2819 (1991)

Shoichiro Tokutomi：“前腺素 E_1 给药对器官功能的影响” 现代医学 23. 2815-2819 (1991)