THE EFFECTS OF STELLATE GANGLION BLOCK TOGETHER WITH OXYGEN.CARBON DIOXIDE OR PROSTAGLANDIN E1 ON CRANIAL CIRCULATION

本实验研究了左侧星状神经节阻滞联合吸入5%二氧化碳或静脉注射前列腺素E_1(PGE_1)对犬脑血流量的影响。用激光多普勒血流仪的盘状探头测量大脑皮质表面的脑血流量。左、右颈总动脉血流量(Ca-BF)和左椎血流量(VBF)显著增加，而脑血流量(CBF)显著降低。吸入5%CO2可引起高碳酸血症(PaCO_2：50 mm Hg)，增加脑血流量。提示SGB可增加SGB侧颈外血流量，但不增加颈内血流量，因此CO2吸入对CBF障碍有效，而不是SGB。PGE1 200 ng/kg/min通过其直接的血管扩张作用使Ca-BF和VBF增加约10%，但对CBF无影响。SGB后，PGE_1的作用明显增强，SGB侧的Ca-BF和VBF增加，提示PGE_1对颈外动脉、椎动脉和SGB均有扩张血管的作用，且与交感神经节阻滞有明显的协同作用。因此，SGB联合前列腺素E_1治疗颈外动脉和椎动脉供血不足更为有效。

I studied the effects of left stellate ganglion block (LtSGB) used together with 5% CO2 inhalation or intravenous prostaglandin E1 (PGE1) for cerebral blood flow (CBF) in dogs. CBF was measured at the surface of cerebral cortex using disc-type-probe of laser doppler flow meter. LtSGB didn't change blood pressure, heart rate and cardiac output.LtSGB significantly increased left common carotid blood flow (Ca-BF) and left vertebral blood flow (VBF), but decreased CBF in SGB side. Inhalation of 5% CO2 induced hypercapnia (PaCO2:50mmHg) and increased CBF. These findings suggest that SGB increase external carotid blood flow in SGB side, but not internal carotid blood flow, therefore CO2 inhalation is effective for disturbance of CBF rather than SGB.The dose of 200ng/kg/min of PGE1 increased Ca-BF and VBF as much as approximately 10% by its direct vasodilative action, but didn't change CBF. After SGB, the effect of PGE1 was augumented clearly at the rate of increase of Ca-BF and VBF in SGB side.These findings suggest PGE1 has vasodilative effects for external carotid artery and vertebral artery as well as SGB,and remarkable synergic effects related to the sympathetic ganglion block. So, SGB using together with PGE1 is more effective for blood insufficiency of the region of external carotid artery and vertebral artery.