Diveropment of alpha-TCP/DCPD Bioactive Bone Cement

α-TCP/DCPD生物活性骨水泥的开发

• 批准号: 02670666
• 负责人: MORITA Masafumi
• 金额: $ 1.22万
• 依托单位: Kitasato University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670666/
• 关键词: Bioactive Bone Cement; alpha-TCP; Joint Prosthesis; Biocompatibility; 複合材料; 骨親和性

1. The ratio of compositions alpha -TCP/DCPD and the strengthThe maximum strength of bone cement was obtained at the alpha -TCP added 10% DCPD and the ratio of bone cement powder and solution. Three days after mixing. the maximum strength of 57MPa was appeared and the cement was weekend gradually.2. The Viscosity of cement pasteThis cement will be used for the perpase of fixation of artificial joint or filling material of bone defect. Due to these uses, the cement should liave suitable viscosity for easy treatment. The viscosity : will be governed with the contents of powder and liquid. Then we are ovser ved that 10% of DCPD added cement mixed with two times much of liquid was most suitable.3. Biocompatibility test for the bone cementIntramedulary canal of femur of living rabbit was drilled from the distal end to 2 cm length proximal direction. And then the cement paste Was injected through the canal. After 0.5 and I years, we preparated some bone tissue samples. of the rabbits and observed the histrogy. But, no information was observed at the interface of bone tissue.

1. α -TCP/DCPD的配比及强度在α -TCP添加量为10% DCPD、骨水泥粉与溶液的配比下获得骨水泥的最大强度。混合后三天。最大强度达到57MPa，水泥逐渐趋于周末化。本产品主要用于人工关节的固定或骨缺损的填充物。由于这些用途，水泥应具有合适的粘度，以便于处理。粘度：由粉末和液体的含量决定。结果表明，水泥中DCPD的掺量为10%，液体掺量为2倍最合适。骨水泥生物相容性试验活体兔股骨髓内管自远端向近端钻孔2 cm。然后通过管道注入水泥膏。经过0.5年和1年，我们准备了一些骨组织样本。并观察其组织学变化。但在骨组织界面未见相关信息。

项目成果

森田 真史: "バイオアクティブ骨セメント(リン酸カルシウム)の生体親和性" Mebio. 8(9). 5 (1991)

Masashi Morita：“生物活性骨水泥（磷酸钙）的生物相容性”Mebio 8(9) 5 (1991)。

有富 寛,森田 真史: "抗生剤混入による骨セメントの強度低下" 関節外科. 11(1). (1992)

Hiroshi Aritomi、Masashi Morita：“抗生素污染导致骨水泥强度下降”关节外科11(1)。