Effects of Tooth-Pain on the Lateral Hypothalamus, the feeding center

牙痛对进食中枢外侧下丘脑的影响

• 批准号: 02670838
• 负责人: HAMBA Michiko
• 金额: $ 1.41万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670838/
• 关键词: Tooth-Pain; Feedin Center; Lateral Hypothlamus; Nociceptive Profection; Trigeminal Afferents; lateral hypothalamus; tooth pulp; projection; pain; Periaquaeductal gray; feeding center; trigeminal afferents

The response of the rat lateral hypothalamic(LEA)neurons to tooth pulp electrical stimlation and the sensory projection pathway from the inusor pulp to the LHA were studied by electrophysiology and histology. 1)IIiA neurons that responded to contralateral lower incisor pulp stimulation were found in the lateral part of the LHA, These neurons also responded to intensive tail pinch, but not to innocuous stimuli nort appliedglucose. 2)Histological study after infection of WGA-HRP into the lateral part of the LHA revealed many retrogradely labeled neurons in the ventral part of the periventricular gray(FVG)in the mesencephalon. 3)The FVG neurons responded antidromically to LHA stimulation and-tb contralateral lower incisor pulp stimulation. 4)After injection of WGA-HRP into the ventral portion of the FVG many labeled cells were found in the contralateral subnucleus caudalis in the spinal tract of the trigeminal nucleus(NTST)where termination of the pulpal afferent was previously reported. It is thus suggested that the FVG is the most likely site of transmission relay of nociceptive inputs from incisors to the LHA.

用电生理学和组织学方法研究了大鼠下丘脑外侧核(LEA)神经元对牙髓电刺激的反应，以及从入髓到LHA的感觉投射通路。1)LHA外侧区可见对侧下切牙髓刺激有反应的IIIA神经元，这些神经元对强烈的挤压尾巴也有反应，但对施加葡萄糖的无害刺激没有反应。2)WGA-HRP感染LHA外侧区后的组织学观察显示，在中脑的脑室周围灰质(FVG)腹侧部有大量逆行标记神经元。3)FVG神经元对LHA刺激和对侧下切牙髓刺激有逆行反应。4)将WGA-HRP注射到FVG腹侧后，在三叉神经脊束核(NTST)的对侧尾侧亚核(NTST)内发现了许多标记细胞。因此，FVG是最有可能将伤害性信息从切牙传递到下丘脑的部位。

项目成果

HAMBA,M.& HISAMITSU,H.: "Toothーpain pathway from the Periventricular Gray to the Hypothalamus." The Journal of Dental Research. 70. (1991)

HAMBA, M. 和 HISAMITSU, H.：“从脑室周围灰质到下丘脑的牙痛通路”，《牙科研究杂志》70。（1991 年）

HAMBA, M. & HISAMITSU, H.: "Tooth Pain Pathway from the Periventricular Gray to the Lateral Hypothalamus" The Journal of Dental Research. 70. 800 (1991)

汉巴，M.

HAMBA,M.,HISAMITSU,H.& MURO,M.: "NOCICEPTIVE PROJECTION FROM TOOTH PULP TO THE LATERAL HYPOTHALAMUS IN RATS" BRAIN RESEARCH BULLETIN. 25. 355-364 (1990)

汉巴，M.，久光，H.

HAMBA,M.& HISAMITSU,H.: "TOOTH PAIN PATHWAY FROM THE PERIVENTRICULAR GRAY TO THE LATERAL HYPOTHALAMUS." THE JOURANAL OF DENTAL RESEARCH. 70. 800 (1991)

汉巴，M.

HAMBA M.: "SOMATOSENSORY PROJECTION FROM INCISOR PULP TO THE LATERAL HYPOTHALAMUS." THE JAPANESE JOURNAL OF PHYSIOLOGY. 40. 195 (1990)

HAMBA M.：“从门牙髓到外侧下丘脑的体感投射。”