权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The analyses of Extraordinary Excitability or Pain in the Jaw and Neck Muscles due to the Pulpal and/or Periodontal Diseases

牙髓和/或牙周疾病引起的下颌和颈部肌肉异常兴奋或疼痛的分析

基本信息

批准号：
02670850
负责人：
SUNAKAWA Mitsuhiro
金额：
$ 1.41万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

Neck and/or Jaw muscle pain is sometimes observed in patients suffering from pulpal and/or periodontal diseases. It is reasonable to consider that these symptoms were caused by the extraordinary excitability of the muscles. The purpose of this research project was to elucidate the muscle pain mechanisms. In a clinical study, the electromyogram of neck and jaw muscle was analyzed in human subjects, and in a basic study, the neurophysiological mechanisms underlying these symptoms were studied in animal experiments. The conclusions were as follows :1. The electromyograms of the masseter muscle(MM)and the sternocleidomastoid muscle(SCMM)were obtained with surface electrodes on both sides in healthy subjects and temporo-mandibular joint dysfunction(TMJD)patients. (1)The SCMM activity corresponded to the MM one in healthy and TMJD subjects, when they moved the mandibular without food rhythmically. (2)In healthy subjects, the SCMM activity was also corresponded to the MM one in case of mastication. While, in TMJD subjects, the former was rather active during the whole stage. of masticatory movement, and showed no harmony with the latter.2. The cervical inferior alveolar nerve-driven neurons(IANDN)were searched for in cats anesthetized with alpha-chloralose, and their response properties were analyzed in respects to the peripheral inputs. (1)Some of the IANDNS were identified as the spino-thalamic neurons(IAND-STN)using collision test. (2)These neurons seemed to relay the sensory information from the tooth pulp or the periodontal tissue. (3)Onto the non-projection IANDN, neck muscle inputs were converged. It might be occurred that neck muscle sensory inputs'integrated into the trigeminal ones in the cervical spinal cord.These results suggest that extraordinary trigeminal sensory inputs may evoke the abnormal reflex resulting in the neck muscle excitation.

颈部和/或颌肌肉疼痛有时在患有牙髓和/或牙周疾病的患者中观察到。有理由认为这些症状是由肌肉的异常兴奋性引起的。本研究项目的目的是阐明肌肉疼痛的机制。在临床研究中，分析了人类受试者的颈部和下颌肌肉的肌电图，在基础研究中，在动物实验中研究了这些症状背后的神经生理机制。主要结论如下：1.应用表面电极对正常人和颞下颌关节功能障碍患者的咬肌和胸锁乳突肌进行肌电图检测。（1）正常人和TMJD受试者在不进食的情况下有节律地移动下颌骨时，SCMM活动与MM活动相对应。(2)In健康人咀嚼时SCMM活性与MM活性也呈一致性。而TMJD患者则表现为前者在整个阶段都比较活跃。与咀嚼运动不协调.在α-氯醛糖麻醉的猫中寻找颈部下肺泡神经驱动神经元（IANDN），并分析其对外周输入的反应特性。（1）碰撞实验证实部分IANDNS为脊髓-丘脑神经元（IAND-STN）。（2）这些神经元似乎传递来自牙髓或牙周组织的感觉信息。（3）在非投射的IANDN上，颈部肌肉的输入信号会聚。颈肌感觉输入在颈髓中可能与三叉神经感觉输入整合，提示三叉神经异常感觉输入可能引起异常反射，引起颈肌兴奋。