Automatic identification of early bone loss patterns from radiographs invisible to human eyes for early periodontal disease diagnosis and prevention

从人眼看不见的射线照片中自动识别早期骨质流失模式，用于早期牙周病的诊断和预防

• 批准号: 10723693
• 负责人: Jay Patel
• 金额: $ 16.09万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723693
• 关键词: Adult; Affect; Algorithms; Alveolar Bone Loss; American; Area Under Curve; Artificial Intelligence; Assessment tool; Biological; Bone Density; Censuses; Clinical; Clinical Decision Support Systems; Computer Vision Systems; Computer software; Data; Data Set; Databases; Decision Making; Dental; Dental Clinics; Dental Informatics; Dental Records; Dental Schools; Dentistry; Dentists; Detection; Deterioration; Development Plans; Diagnosis; Diagnostic; Disease; Documentation; Early Diagnosis; Early identification; Electronics; Ensure; Evidence based practice; Exposure to; Eye; Frequencies; Funding; Goals; Habits; Health; Health Care Costs; Health Status; Human; Image; Image Enhancement; Lesion; Literature; Manuals; Measurement; Measures; Medical Records; Medicine; Mentors; Methods; Minerals; Modeling; National Institute of Dental and Craniofacial Research; Natural Language Processing; Noise; Oral; Oral health; Pain; Patient Care; Patient-Focused Outcomes; Patients; Pattern; Performance; Periodontal Diseases; Periodontitis; Prevalence; Prevention; Prevention strategy; Preventive; Preventive care; Privatization; Process; Prognosis; Psyche structure; Quality of life; Radiology Specialty; Reporting; Research; Research Personnel; Risk; Risk Assessment; Scientist; Systemic disease; Technology; Testing; Therapeutic; Time; Tooth Diseases; Tooth Loss; Training; Translating; Translations; Visit; accurate diagnosis; alveolar bone; bone; bone loss; career development; clinical practice; community based participatory research; data quality; deep learning algorithm; deep learning model; demographics; design; diagnostic accuracy; disability; disease diagnosis; disorder prevention; empowerment; high risk; image processing; imaging informatics; improved; lectures; novel; novel strategies; periapical; predictive modeling; prevent; programs; protective factors; prototype; psychologic; radiological imaging; skills; social; social health determinants; tool; treatment planning

Abstract: Periodontitis is the second most prevalent but preventable dental disease affecting over 64 million Americans and responsible for tooth loss, functionality limitations, pain, and poor quality of life. Thus, early diagnosis and preventive therapeutics are imperative in clinical practice to prevent disease initiation and progression. However, by the time dentists can observe the first bone loss patterns in radiographs to diagnose periodontitis, 30-50% deterioration (periodontal bone damage) has already occurred, which is not visible to human eyes. Clinical decision support systems are designed to identify high-risk periodontitis patients for prevention; however, they are not widely used in clinical practice because of the suboptimal prediction performance and lack of diverse predictive features (early bone loss lesions) for prediction. Therefore, there is an unmet need for a tool that can detect early bone loss patterns invisible to human eyes to alert dentists for early diagnosis and preventive care. Dr. Patel has developed an artificial intelligence (AI) empowered prediction model for periodontitis that utilizes more than 150 distinct variables (e.g., social determinants of health, medical records, lab reports, CDC census data, financial data, etc.) for prediction, which aren't well understood in the existing literature. However, this model lacks dental imaging data such as bone pattern, bone density, pixel intensity, and other imaging predictive features, which have a high potential to improve prediction accuracy. The early bone mineral changes in alveolar bone for early diagnosis have been studied in biological studies; however, the transition of these findings at the chairside is limited. AI and computer vision can bridge this gap and help identify early bone loss patterns from radiographs invisible to human eyes. Therefore, the objective of this project is to develop three automated computer vision algorithms: 1) to improve the extraction of diagnostically meaningful information from periapical radiographs, 2) to determine the extent of bone loss information from radiographs, and 3) build a prediction model to identify early bone loss patterns from radiographs before disease initiation and progression. Enhanced and consistent radiographs will improve diagnostic accuracy & reduce radiographic exposure, automatic bone loss measurement will reduce diagnostic discrepancies, and early bone loss detection will identify high-risk patients to take preventive approaches. The candidate, Dr. Patel's goal is to become an independent PI in dental informatics and develop cutting-edge technologies to generate practice- based evidence (using data-driven methods) to improve patient care and outcomes. A funded K08 proposal will allow Dr. Patel to develop the skills necessary to complete the proposed research (training in computer vision & radiology) and become an independent research scientist (training in didactic mentoring, lecturing, & grantsmanship). Dr. Patel has formed a team of five mentors with expertise in clinical dentistry, computer vision, radiology, and periodontology to provide high-quality, diverse scientific, collegial support and state-of-the-art facilities to ensure the successful completion of this proposed career development goals and research program.

摘要：牙周炎是第二大流行但可预防的牙病，影响超过6400万人