Bioinorganic Chemistry on Vanadium Complexes possessing Anti-diabetic Action

具有抗糖尿病作用的钒配合物的生物无机化学

• 批准号: 02670982
• 负责人: SAKURAI Hiromu
• 金额: $ 1.47万
• 依托单位: Kyoto Pharmaceutical University (1991)The University of Tokushima (1990)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670982/
• 关键词: insulin-like action; vanadyl compounds; diabetes; streptozotocin; blood glucose level; vanadyl-cysteine methyl ester; vanadium determination; adipocites; ESR(電子スピン共鳴法); 遊離脂肪酸; 脂肪細胞; 電子スピン共鳴(ESR)

We investigated whether vanadyl ion, which is less toxic than vanadate to rats, has an insulin-like effect in rats with streptozotocin (STZ) -induced diabetes. When rats with STZ -induced diabetes were given a daily i. p. injection of vanadyl sulfate or a daily p. o. admistration of vanadyl complexes like vanadyl-cysteine methyl ester (V-Cys), their blood glucose levels decreased to the normal level within 2 days and remained low for 12 weeks. These treatments did not affect their low plasma insulin levels. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium(-90%)in their tissues was present as a vanadyl form (VO^<2+>). Vanadium treatments accelerated glucose incorporation into adipocytes of rats suggesting that the action of vanadyl ion is peripheral. These results including that V-Cys showed anti-diabetic action when it was given orally, suggest that the vanadyl complexes are possible to use clinically to treat diabetes

我们研究了钒离子，它对大鼠的毒性比钒酸盐小，是否对链脲佐菌素(STZ)诱导的糖尿病大鼠有胰岛素样作用。STZ诱导的糖尿病大鼠每日ip硫酸钒或每日口服钒-半胱氨酸甲酯(V-Cys)等钒配合物后，血糖水平在2天内降至正常水平，并维持在较低水平12周。这些治疗并不影响他们较低的血浆胰岛素水平。定量电子自旋共振(ESR)谱显示，它们组织中的大部分钒(-90%)以钒的形式存在(VO^&lt；2+&gt；)。钒处理促进了大鼠脂肪细胞的葡萄糖掺入，提示钒离子的作用是外围的。这些结果，包括V-半胱氨酸口服时表现出抗糖尿病作用，表明钒配合物有可能用于临床治疗糖尿病

项目成果

北村 桂雄,斉藤 寛,桜井 弘,干熊 正彦 編著: "薬学の機器分析" 廣川書店(株), 389 (1991)

北村克夫、斋藤博、樱井博、日隈正彦（编）：《药学中的仪器分析》广川书店，389（1991）

H.Sakurai and K.Tsuchiya: "A Biomimetic Model of Vanadiumーcontaining Bromoperoxidase" FEBS Letters. 260. 109-112 (1990)

H. Sakurai 和 K. Tsuchiya：“含钒溴过氧化物酶的仿生模型”FEBS Letters 260. 109-112 (1990)。

桜井 弘: "バナジウムの生体濃縮と生理作用" 細胞. 22. 13-17 (1990)

Hiroshi Sakurai：“钒的生物富集和生理效应”Cell。22. 13-17 (1990)

H. Sakurai, K. Tsuchiya, M. Nukatsuka, M. Sofue, and J. Kawada: "Insulin-like effect of vanadyl ion on streptozotocin- induced deabetic rats" J. Endocrinology. 126. 451-459 (1990)

H. Sakurai、K. Tsuchiya、M. Nukatsuka、M. Sofue 和 J. Kawada：“氧钒离子对链脲佐菌素诱导的糖尿病大鼠的胰岛素样作用”J. 内分泌学。