Bioinorganic Chemistry on Vanadium Complexes possessing Anti-diabetic Action

我们研究了钒氧离子，这是毒性比钒酸盐对大鼠，是否有胰岛素样作用，在大鼠与链脲佐菌素（STZ）诱导的糖尿病。当STZ诱导的糖尿病大鼠每天i. p.注射硫酸氧钒或每日p.o.给予氧钒络合物如氧钒-半胱氨酸甲酯（V-Cys），其血糖水平在2天内降低至正常水平，并保持低水平12周。这些治疗并未影响其低血浆胰岛素水平。定量电子自旋共振（ESR）光谱法显示，它们组织中的大部分钒（~ 90%）以氧钒形式（VO^<2+>）存在。钒酸盐处理加速了葡萄糖掺入大鼠脂肪细胞，表明钒氧离子的作用是外周的。这些结果包括V-Cys口服具有抗糖尿病作用，提示钒氧配合物有可能用于临床治疗糖尿病

We investigated whether vanadyl ion, which is less toxic than vanadate to rats, has an insulin-like effect in rats with streptozotocin (STZ) -induced diabetes. When rats with STZ -induced diabetes were given a daily i. p. injection of vanadyl sulfate or a daily p. o. admistration of vanadyl complexes like vanadyl-cysteine methyl ester (V-Cys), their blood glucose levels decreased to the normal level within 2 days and remained low for 12 weeks. These treatments did not affect their low plasma insulin levels. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium(-90%)in their tissues was present as a vanadyl form (VO^<2+>). Vanadium treatments accelerated glucose incorporation into adipocytes of rats suggesting that the action of vanadyl ion is peripheral. These results including that V-Cys showed anti-diabetic action when it was given orally, suggest that the vanadyl complexes are possible to use clinically to treat diabetes