Active oxygen-induced vascular damage and its protection.
活性氧引起的血管损伤及其保护。
基本信息
- 批准号:02671054
- 负责人:
- 金额:$ 1.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1990
- 资助国家:日本
- 起止时间:1990 至 1991
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. Dietary vitamin E reduced the decreases of the histamin-induced, endothelium-dependent vasodilatation and associated production of cGMP in rat thoracic aorta induced by increase of age(from 3-weeks to 40-weeks). The level of plasma lipid peroxides increased with increase of age was further increased in vitamin E-deficient rats and decreased in vitamin E-supplemented rats. Histamin-induced vasodilatation and cGMP formation in E-deficient rats were decreased with increase of lipid peroxides in aorta by incubation with ascorbic acid and Fe^<2+>, which are known to initiate lipid peroxidation in vitro. The decreases of vasodilatation and cGMP synthesis by lipid peroxidation were suppressed in E-supplemented rats. These results indicate that vitamin E may have a protective effect on decrease -of vasodilatation associated with age and in vitro lipid peroxidation due to its antioxidant activity.2. Dietary vitamin E protected the fetal ischemic distress induced by clampig, the uterotubal ve … More ssels of pregnant rats, possibly by inhibiting lipid peroxidation increased in the fetal tissues such as brain by reperfusion after ischemia. Moter disturbances induced by ischemic compression injury of rat spinal cord were reduced by vitamin E-supplementation, but enhanced by vitamin E deficiency. The increase in the level of lipid peroxides in the spinal cord by reperfusion after ischemia increased with decrease in the dietary level of vitamin E.3. The site-specific mechanism of initiation of H202-dependent, lipid peroxidedependent and peroxide-independent lipid peroxidations catalyzed by chelatediron in micelle membranes was investigated. Among the chelaters examined such as EDTA, EGTA, DETAPAC, and deferoxamine, iron-NTA(nitrilotriacetic acid), which was reported to have carcinogenic effect in kidney, showed the highest activity for the initiation of these three lipid peroxidations, suggesting that the strong prooxidant effects of iron-NTA is a major cause of its renal carcinogenicity. Less
1.膳食维生素E可减少由年龄增加(从3周龄至40周龄)引起的大鼠胸主动脉组胺诱导的内皮依赖性血管舒张和相关cGMP产生的减少。血浆过氧化脂质水平随年龄增加而增加,维生素E缺乏大鼠进一步增加,维生素E补充大鼠降低。维生素C和Fe^<2+>可在体外引发脂质过氧化反应,在E缺乏大鼠中,随着主动脉脂质过氧化反应的增加,组胺诱导的血管舒张和cGMP形成减少。补充维生素E可抑制脂质过氧化引起的血管舒张和cGMP合成的减少。这些结果表明,维生素E可能具有保护作用的减少血管舒张与年龄和体外脂质过氧化作用,由于其抗氧化活性。膳食维生素E对子宫输卵管结扎引起的胎儿缺血性窘迫有保护作用 ...更多信息 孕鼠脑缺血再灌注后,胎鼠脑组织脂质过氧化反应增强,SSELS可能通过抑制脂质过氧化反应而增强。补充维生素E可减轻大鼠脊髓缺血性压迫损伤引起的运动障碍,而缺乏维生素E则加重运动障碍。缺血后再灌注脊髓中脂质过氧化物水平的增加随着维生素E.3饮食水平的降低而增加。研究了胶束膜中螯合二铁催化H2 O2依赖性、脂质过氧化物依赖性和非过氧化物依赖性脂质过氧化反应的位点特异性机制。在所检测的螯合剂如EDTA、EGTA、NH 4PAC和去铁胺中,铁-NTA(次氮基三乙酸)(据报道其在肾脏中具有致癌作用)显示出最高的引发这三种脂质过氧化的活性,这表明铁-NTA的强促氧化作用是其肾脏致癌性的主要原因。少
项目成果
期刊论文数量(37)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fukuzawa, K., Minami, K., Moritoki, H.: "Effect of dietary vitamin E on decrease of endothelium-dependent vasodilatation associated with age and in vitro lipid peroxidation." Active Oxygens, Lipid Peroxides and Antioxidants ; Elsevier, Amsterdam. (1992)
Fukuzawa, K.、Minami, K.、Moritoki, H.:“膳食维生素 E 对减少与年龄和体外脂质过氧化相关的内皮依赖性血管舒张的影响。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Fukuzawa,K.,Fujii,T.,Mukai,K.: "Peroxideーdependent and ーindependent lipid peroxidation catalyzed by chelated iron." Archives Biochemistry and Biophysics. 290. 489-496 (1991)
Fukuzawa, K.、Fujii, T.、Mukai, K.:“螯合铁催化的过氧化物依赖性和非依赖性脂质过氧化。”档案生物化学和生物物理学 290. 489-496 (1991)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
福沢 健治: "合成抗酸化剤" 活性酸素・フリ-ラジカル. 2. 182-196 (1991)
Kenji Fukuzawa:“合成抗氧化剂”活性氧和自由基。2. 182-196 (1991)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
藤井 智仁,池端 航,福沢 健治: "鉄錯体(FeーNTA)によって誘導される脂質過酸化反応" 過酸化脂質研究. 15. 23 (1991)
Tomohito Fujii、Wataru Ikebata、Kenji Fukuzawa:“铁复合物 (Fe-NTA) 诱导的脂质过氧化”脂质过氧化物研究。 15. 23 (1991)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
平本 泰志,藤井 智仁,福沢 健治: "過酸化脂質依存性脂質過酸化反応に対するαーTocpherolの作用" ビタミンE研究の進歩. 1. 153-157 (1990)
Yasushi Hiramoto、Tomohito Fujii、Kenji Fukuzawa:“α-生育酚对脂质过氧化物依赖性脂质过氧化反应的影响”维生素 E 研究进展 1. 153-157 (1990)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
FUKUZAWA Kenji其他文献
FUKUZAWA Kenji的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('FUKUZAWA Kenji', 18)}}的其他基金
Observation of nm-sliding gap shape for formulation of theory of boundary lubrication
观察纳米滑动间隙形状以制定边界润滑理论
- 批准号:
24656112 - 财政年份:2012
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Multilateral measurement of phenomena of thin lubrication with a nm-thick lubricant film
纳米厚润滑油膜薄润滑现象的多边测量
- 批准号:
23246031 - 财政年份:2011
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Dual-axis micro friction force miscroscopy pobe for dynamic measurements
用于动态测量的双轴微摩擦力显微镜探针
- 批准号:
20360077 - 财政年份:2008
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Systematic elucidation of nano-lubrication properties of ultra-thin liquid lubricant films
系统阐明超薄液体润滑油膜的纳米润滑特性
- 批准号:
17206014 - 财政年份:2005
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Measurement of nanotribological properties of molecularry thin lubricant by using optical fiber probe
光纤探针测量稀分子润滑剂纳米摩擦学性能
- 批准号:
15360084 - 财政年份:2003
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Imaging of a molecularly thin lubricant film on a magnetic disk by using ellipsometric microscopy
使用椭圆偏振显微镜对磁盘上的分子薄润滑膜进行成像
- 批准号:
13450065 - 财政年份:2001
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
ICF: Microfluidic investigation of the role of transcapillary resistance and vascular permeability/normalisation on cancer outcomes via vasodilation
ICF:微流体研究跨毛细血管阻力和血管通透性/正常化通过血管舒张对癌症结果的影响
- 批准号:
MR/Y000609/1 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Research Grant
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
Mito-Frail 试验:MitoQ 对体弱老年人的血管舒张、活动能力和认知能力的影响
- 批准号:
10572663 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Pericyte function in anesthetic-induced vasodilation and developmental neurotoxicity
麻醉诱导的血管舒张和发育神经毒性中的周细胞功能
- 批准号:
10811278 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
The Impact of Limb Microvascular Vasodilation on Arterial Wave Reflection
肢体微血管舒张对动脉波反射的影响
- 批准号:
575521-2022 - 财政年份:2022
- 资助金额:
$ 1.15万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
妊娠和先兆子痫中的 H2S 与子宫血管舒张
- 批准号:
10274204 - 财政年份:2021
- 资助金额:
$ 1.15万 - 项目类别:
H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
妊娠和先兆子痫中的 H2S 与子宫血管舒张
- 批准号:
10454412 - 财政年份:2021
- 资助金额:
$ 1.15万 - 项目类别:
H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
妊娠和先兆子痫中的 H2S 与子宫血管舒张
- 批准号:
10646404 - 财政年份:2021
- 资助金额:
$ 1.15万 - 项目类别:
Red light mediated trafficking of microvesicles as a mechanism for vasodilation
红光介导的微泡运输作为血管舒张的机制
- 批准号:
10477186 - 财政年份:2020
- 资助金额:
$ 1.15万 - 项目类别:
Large coronary artery vasodilation in hypoxia
缺氧时冠状动脉血管扩张
- 批准号:
560579-2020 - 财政年份:2020
- 资助金额:
$ 1.15万 - 项目类别:
University Undergraduate Student Research Awards