Peptide Nucleic Acid Based Sensors and Devices - An Investigation into PNA Versatility for Emerging Gene Technologies

基于肽核酸的传感器和设备 - 针对新兴基因技术的 PNA 多功能性的研究

• 批准号: DP0343096
• 负责人: Prof Steven Langford
• 金额: $ 19.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-02 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343096
• 关键词: Peptide; Nucleic; Acid; Based; Sensors

Peptide nucleic acids (PNAs) are analogues of DNA that may have important implications as therapeutic agents for the cure of diseases based on genetic defects. The attributes of PNAs that make them potentially viable as a drug are also well suited to their development as sensors and molecular devices. In this proposal, we wish to develop a series of PNAs containing photoactive elements (a) as alternatives to commercially-available fluorophores, (b) for the early detection of neurodegenerative diseases and (c) to contribute to one of Science's most debated issues i.e. "does DNA mediate electron transport?"

肽核酸（PNAs）是DNA的类似物，其作为治疗基于遗传缺陷的疾病的治疗剂可能具有重要意义。 PNA的属性使它们作为药物具有潜在的可行性，也非常适合它们作为传感器和分子器件的发展。 在这项提议中，我们希望开发一系列含有光敏元素的PNA，（a）作为市售荧光团的替代品，（B）用于神经退行性疾病的早期检测，（c）为科学界最具争议的问题之一，即“DNA介导电子传递吗？"