Joint Research on Pathogenesis of Vogt-Koyanagi-Harada Disease

Vogt-小柳-原田病发病机制的联合研究

基本信息

批准号：
03044112
负责人：
INOMATA Hajime
金额：
$ 2.88万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

In order to clarify the pathogenesis of Vogt-Koyanagi-Harada disease, joint study was performed between Kyushu University and University of Southern California from 1991 to 1993. Methods of the joint study were exchanges the data of uveitis patients and the clinical and basic knowledge accumulated in both institutions. Particular attention was focused on whether or not there is fundamental difference clinically and histopathologically in patients with Vogt-Koyanagi-Harada disease between the two different countries.1. Vogt-Koyanagi-Harada disease in University of Southern California was mostly seen among Mexican and oriental immigrants. Clinical features of the disease are quite similar to those seen in the patients of Japan.2. Cytomegalovirus retinitis, toxoplasmic retinochoroiditis, and cryptococcus choroiditis, which occur as an opportunistic infection in AIDS patients, were the most serious disease in uveitis of University of Southern California.3. Class II major histocompatibility … More complex was expressed in the choroidal melanocytes as well as in the endothelium of choriocapillaris in autopsy eyes from two Japanese patients with Vogt-Koyanagi-Harada disease. The results indicate that choroidal melanocytes appear to play a pathogenic role in Vogt-Koyanagi-Harada disease.4. The cell-mediated immunological reaction similar to those in the choroid was detectd in the lesion of vitiligo of a patients with Vogt-Koyanagi-Harada disease.5. Histopathological features of eyes with Behcet's disease were retinal vasculitis and vitreo-retinal proliferative changes associated with choroidal neovascularization.6. Expression of Intercellular adhesion molecule-1(ICAM-1) was demonstrated in the rat corneal endothelium in experimental uveitis induced by interphotoreceptor peptides (R-4) as an immunogen using immunohistochemical methods.7. The results of the joint study were published in a book chapter of "Ocular Infection and Immunity" entitled on "Vogt-Koyanagi-Harada Syndrome". The book will be published by Mosby Year Book in 1993. Less

为了阐明Vogt-Koyanagi-Harada疾病的发病机理，从1991年至1993年进行了京都大学和南加州大学之间的联合研究。联合研究的方法是交换了葡萄膜炎患者的数据以及两家机构中积累的临床和基本知识。特别关注的是，在两个不同国家之间的Vogt-Koyanagi-Harada疾病的患者中，在临床和历史上是否存在基本差异。1。南加州大学的Vogt-Koyanagi-Harada病大多在墨西哥和东方移民中出现。该疾病的临床特征与日本患者中看到的临床特征非常相似。2。在艾滋病患者中，作为选择性感染的巨细胞病毒性视网膜炎，毒质视网膜毒素和脉络膜脉络膜炎是南加州大学葡萄炎最严重的疾病。3。 II类主要的组织相容性……在脉络膜黑素细胞以及脉络膜毛细血管内皮中表达了更复杂的尸检，来自两名日本Vogt-Koyanagi-Harada病患者的尸检。结果表明，脉络膜黑素细胞似乎在Vogt-Koyanagi-Harada病中起致病作用。4。在患有Vogt-Koyanagi-Harada病的患者的白癜风病变中检测到与脉络膜中类似的细胞介导的免疫反应。5。贝塞特氏病的眼睛的组织病理学特征是视网膜血管炎和与脉络膜新生血管相关的玻璃体视网膜增殖变化。6。使用免疫组织化学方法，在大鼠角膜森植物中，在大鼠角膜森植物中证明了细胞间粘附分子-1（ICAM-1）的表达。7。联合研究的结果发表在一章中，题为“眼部感染和免疫力”，题为“ Vogt-Koyanagi-Harada综合征”。这本书将由莫斯比年鉴在1993年出版。