Total Synthesis of Biologically Active Compounds derived from

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Recent developments of natural products clemistry have unveiled structures and biological activities of some marine natural products. We have quite interested in their efficient synthesis suitable for the large scale production to investigate their biological profiles in detail. In this research, we have focused our attention to the synthesis of calyculins and theonellamide Fisolated from marine sponges.The molecule of calyculins was divided into four fragments, three of which were synthesized stereoselectively in an efficient manner. We are now synthesizing the remaining fragment and constructing the whole molecule.Theonellamide F, a bicyclic dodecapeptide, contains various unusual amino acids. We first synthesized these amino acids, and then accomplished the synthesis of both the southern and northern hemispheres. We are now constructing the whole molecule of theonellamide F from the southern hemisphere.