Nondestructive chemical imaging of trace elements in biochemical tissues by synchrotron radiation induced x-ray fluorescence analysis.

通过同步加速器辐射诱导 X 射线荧光分析对生化组织中的微量元素进行无损化学成像。

• 批准号: 03670261
• 负责人: SHIMOJO Nobuhiro
• 金额: $ 1.09万
• 依托单位: The University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670261/
• 关键词: SR-XRF; distribution; Zn; Cu; Se; Hg; BPH; cancerous-tissue; 非破壊放射光X線分析; 有機水銀; 腎; SOD; 2次元分布; イメ-ジング; 水銀毒性; 相互作用

The results of the studies carried out for three years, 1991 to 1993, can be summarized as follows.1. The dynamics of the brain distribution of Hg, Zu, Cu and Se guinea pig exposed to methylmercury and selenium were examined by x-ray fluorescence imaging utilizing synchrotron radiation (SR-XRF).2. Male Hartley guinea pigs were administered metylmercury chloride and / or sodium selenite every day for ten days. Two dimensional distributions of Hg, Zu, Cu and Se in guinea pig brain were observed by nondestructive x-ray fluorescence imaging. High correlation between Hg and Zn, Cu, Se was observed, whereas much lower correlation was observed for nontreated or only selenium administered guinea pigs.3. The distribution of Zu, Cu and Se for the adult human kindey (20 and 61 year old) were more accumulated in the renal cortex than in the renal medula.4. Cu and Zu were more accumlated in the cancerous tissue which located on the outside of prostate, than the normal tissue. In the case of BPH, high accumulation of both Cu and Zu was observed in the hypertrophic grands than normal tissue.

1991年至1993年三年的研究结果可概括如下：1.方法：1.采用同步辐射X射线荧光成像(SR-XRF)技术，研究甲基汞和硒对汞、锌、铜、硒暴露豚鼠脑内分布的动态影响。雄性Hartley豚鼠每日给予氯化甲基汞和/或亚硒酸钠，连续10天。用非破坏性X射线荧光成像法观察了汞、锌、铜、硒在豚鼠脑内的二维分布。汞与锌、铜、硒有较高的相关性，而未加硒或只加硒的豚鼠相关性较低。锌、铜、硒在成人肾组织(20岁和61岁)中的分布在肾皮质比在肾髓质中积累更多。铜、锌在前列腺癌组织中的蓄积量明显高于正常组织。在良性前列腺增生症中，肥大的腺体中铜和锌的蓄积量均高于正常组织。

项目成果

Kazuo T.Suzuki: "Changes in Element Concentration and Distribution in BreastーMilk Fractions of a Healthy Lactating Mother" Biological Trace Element Research.

Kazuo T.Suzuki：“健康哺乳期母亲母乳成分中元素浓度和分布的变化”生物微量元素研究。

Nobuhiro Shimojo: "NONDESTRUCTIVE SR-XRF IMAGING OF TRACE ELEMENTS IN HUMAN PROSTATE:PROSTATIC CANCER AND BENIGN PROSTATIC HYPERTROPHY." PHPTON FACTORY ACTIVITY REPORT. 10. 93 (1992)

Nobuhiro Shimojo：“人类前列腺中微量元素的非破坏性 SR-XRF 成像：前列腺癌和良性前列腺肥大。”

S.Homma, I.Nakai, N.Shimojo and A.Iida.: "NONDESTRUCTIVE SYNCHROTRON RADIATION X-RAY FLUORESCENCE IMAGING OF TRACE ELEMENTS IN HUMAN KIDNEY." PHOTON FACTORY ACTIVITY REPORT. No.9. 42 (1991)

S.Homma、I.Nakai、N.Shimojo 和 A.Iida.：“人体肾脏中微量元素的非破坏性同步辐射 X 射线荧光成像。”

本間 志乃,下條 信弘: "非破壊放射光蛍光X線分析法による腎臓内微量元素の2次元イメージング(第1報)" 産業医学. 34. 142-143 (1992)

Shino Homma，Nobuhiro Shimojo：“使用非破坏性同步辐射荧光 X 射线分析对肾脏中的微量元素进行二维成像（第一份报告）”工业医学。 34. 142-143 (1992)

石田 弓子 他: "アルミニウム投与による脳内神経伝達物質の変動とリズム変化に関する研究" 茨城県衛生研究所年報. 30. 1-8 (1992)

Yumiko Ishida 等：“铝给药引起的大脑神经递质波动和节律变化的研究”茨城县卫生研究所年度报告 30. 1-8 (1992)。