サイトカインによるIgE抑御機構にもとずくI型アレルギー疾患治療への試み

(2)我们建立了灵敏的检测IL-2、IL-4、IL-6等细胞因子的方法。(3)我们在体外通过人淋巴细胞培养系统证明了硫代马来酸金是一种很强的IL-2诱导剂。(4)我们发现金疗法降低了类风湿性关节炎患者的IgE产生，因此用IL-2、IL-2诱导剂(金)进行免疫治疗有助于I型变态反应性疾病的治疗。

(1) We demonstrated that IgE production induced IL-4 was suppressed by IL-2 invitro and invivo.(2) We established sensitive methods to detect cytokine such as IL-2, IL-4, IL-6 by M.T.T.(3) We showed a Gold thiomalate was a strong IL-2 inducer by human lymphocyte culture system in vitro.(4) We found that IgE production of a patient with Rheumatoid Arthritis was decreased by Gold therapy, so that immunotherapy using IL-2, IL-2 inducer (Gold) was helpful for type I of allergic disease.