权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Experimental transmission of hantavirus infection in laboratory rats

实验室大鼠汉坦病毒感染的实验传播

基本信息

批准号：
03680040
负责人：
DOHMAE Kayoko
金额：
$ 1.41万
依托单位：
Osaka University Rrsearch Institute for Microbial Siseases, Vrant-in-Aid for Scientific Research (c)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03680040/
关键词：
HFRS virus Seoul type B-1 strain maternal immunity natural transmission antibody titer T-cill deficient nude rat

项目摘要

1. In order to study the mechanism of prevalence of Hantavirus infection, protecting effect of antibodies transferred form mother to infant was assessed. antibodys to hantavirus Seolul type B-1 strain. maternally transferred to neonates prevented lethal infection. However, the antibodies were not necessarily active enough to protect against persistent virus infection in neonates, Establishment of persisstent infection depends upon the level of virus titers inoculated,Neonates completely protected form active virus infection by maternal immunity do not show immune response to a secondary challenge of the same virus.2. We have developed a new natural transmission system of hantavirus in laboratory rats between immunologically intact (rnu/+) and their congenitally T-cell deficient nude (rnu/rnu) littermates.Nude rats dicharge more of active infectious viruses to cause prevalence of infection and die when infected. Furthermore, immunologically normal serpositive rats never cause infection to cagemate nude rats. Thus, nude rats are highly susceptible to the hantavirus infection.These laboratory animals and experimental system are useful models to study the mechanism of hantavirus infection.

1. 为了研究汉坦病毒感染流行的机制，评价了母体向婴儿转移抗体的保护作用。汉城B-1型汉坦病毒抗体。母体转移给新生儿可预防致命感染。然而，这些抗体并不一定具有足够的活性来保护新生儿免受持续病毒感染，持续感染的建立取决于接种的病毒滴度水平，新生儿完全免受活性病毒感染，母体免疫对同一病毒的二次攻击没有表现出免疫反应。我们在实验室大鼠中建立了一种新的汉坦病毒在免疫正常（rnu/+）和先天t细胞缺陷裸鼠（rnu/rnu）之间的自然传播系统。裸鼠携带较多的活性感染病毒，引起感染流行，感染后死亡。免疫正常血清阳性大鼠对笼内裸鼠无感染。因此，裸鼠对汉坦病毒感染非常敏感。这些实验动物和实验系统为研究汉坦病毒感染机制提供了有益的模型。