Experimental transmission of hantavirus infection in laboratory rats

1.为探讨汉坦病毒感染的流行机制，对母婴抗体传递的保护作用进行了评价。抗汉坦病毒Seolul B-1株的抗体。母体转移给新生儿可防止致命感染。然而，这些抗体并不一定有足够的活性来保护新生儿免受持续性病毒感染，持续性感染的建立取决于接种病毒的滴度水平，新生儿完全被母体免疫保护免受活动性病毒感染，对相同病毒的二次攻击不显示免疫应答.我们建立了一种新的汉坦病毒在免疫完整（rnu/+）和先天性T细胞缺陷裸鼠（rnu/rnu）之间的自然传播系统，裸鼠分泌更多的活性感染性病毒，导致感染流行，感染后死亡。此外，免疫学正常的血清阳性大鼠从未引起感染cagglutinin裸大鼠。因此，裸大鼠对汉坦病毒感染高度易感，是研究汉坦病毒感染机制的理想实验动物和实验系统。

1. In order to study the mechanism of prevalence of Hantavirus infection, protecting effect of antibodies transferred form mother to infant was assessed. antibodys to hantavirus Seolul type B-1 strain. maternally transferred to neonates prevented lethal infection. However, the antibodies were not necessarily active enough to protect against persistent virus infection in neonates, Establishment of persisstent infection depends upon the level of virus titers inoculated,Neonates completely protected form active virus infection by maternal immunity do not show immune response to a secondary challenge of the same virus.2. We have developed a new natural transmission system of hantavirus in laboratory rats between immunologically intact (rnu/+) and their congenitally T-cell deficient nude (rnu/rnu) littermates.Nude rats dicharge more of active infectious viruses to cause prevalence of infection and die when infected. Furthermore, immunologically normal serpositive rats never cause infection to cagemate nude rats. Thus, nude rats are highly susceptible to the hantavirus infection.These laboratory animals and experimental system are useful models to study the mechanism of hantavirus infection.