Studies on the regulation of gene expression in lymphoid cells.

本项目是为了促进日本和美国免疫学家和分子生物学家之间的合作研究而完成的。在本项目期间，（1）两名日本成员调查员被派往美利坚合众国，（2）在日本福冈举行了关于免疫调节和耐受机制的专题讨论会。(1)派遣日本科学家成员到美国进行合作。(i)T.Kishimoto博士于1992年11月29日至12月5日被派往美国。他访问了位于贝塞斯达的美国国立卫生研究院，与W.E.Paul博士和T.Waldmann博士讨论了通过细胞因子受体的信号传导机制以及免疫疾病中细胞因子基因的异常表达。他还访问了位于洛杉矶的加州大学洛杉矶分校，与O.Martinez-Maza博士安排了一个关于艾滋病病理学的分子生物学解剖的合作项目。(ii)博士一、西川被送往陶斯，新墨西哥州在美国从1月1日至 ...更多信息 1993年2月8日参加B淋巴细胞分化的分子方面的研讨会。在这次研讨会上，他与P.Kincade博士和D.巴尔的摩博士（这个蒙布肖研究计划的成员）以及他们的同事进行了讨论。根据西川博士的报告，p53原癌基因产物参与了前B细胞在V-D-J重组时的细胞周期停滞，他与一些美国研究人员进行了讨论，并成功地安排了这方面的合作研究。那里还报道了抗IL-7受体抑制抗体的制备，西川博士与美国科学家进行了接触，开始了利用该抗体进行B细胞分化的合作。(2)1993年3月2日至3日在福冈举行了关于免疫调节和耐受机制的研讨会。在这次研讨会上，日本和美国在这一领域的顶级科学家做了17个报告。在整个研讨会期间，与会者根据他们最近的知识进行了深入的讨论。除了演讲者之外，还有一百多位日本顶尖免疫学家和年轻科学家齐聚一堂，响应我们的参与号召。本次研讨会主要围绕淋巴细胞的活化与库选择、淋巴细胞生成中的转录因子、淋巴细胞活化中的信号转导等问题进行了研讨，并取得了一定的成果。相信本研究计划已圆满完成，各成员研究者在本研究计划的支持下进行的合作也取得了丰硕的成果。少

This project has been accomplished for the purpose of promoting collaborative studies between Japanese and American immunologists and molecular biologists. During the term of this project (1) two of the Japanese member investigators were sent to the United States of America and (2) the symposium on the mechanisms of immune regulation and tolerance was held in Fukuoka, Japan.(1) Sending of Japanese member scientists to the U.S.A. for collaboration.(i) Dr.T.Kishimoto was sent to the U.S.A. from November 29 to December 5, 1992. He visited NIH in Bethesda for having discussion with Dr.W.E.Paul and Dr.T.Waldmann on the signaling mechanisms through cytokine receptors and on the aberrant cytokine gene expression in immunological disorders. He also made a visit to UCLA in Los Angeles for arranging a collaborative project with Dr.O.Martinez-Maza regarding molecular biological dissection of the pathology of AIDS.(ii) Dr.S.-I.Nishikawa was sent to Taos, New Mexico in the U.S.A. from January 1 to … More February 8, 1993 for attending the symposium on the molecular aspect of B lymphocyte differentiation. In this symposium, he discussed with Dr.P.Kincade and Dr.D.Baltimore (members of this Monbusho Research Program) as well as their colleagues. Based on Dr.Nishikawa's presentation suggesting involvement of p53 proto-oncogene product in the cell cycle arrest of pre-B cells at the V-D-J recombination, he discussed with some American researchers and has successfully arranged a collaborative study in this regard. The preparation of anti-IL-7 receptor inhibitory antibody was also reported there, and Dr.Nishikawa has made a contact with American scientists to start collaboration on B cell differentiation by the use of this antibody.(2) The symposium on the mechanisms of immune regulation and tolerance was held from March 2 to March 3, 1993 in Fukuoka. In this symposium, 17 presentations were made by Japanese and American top-ranking scientists in this field. The participants intensively made discussion based on their very recent knowledge throughout the symposium. In addition to the speakers, over a hundred Japanese leading immunologists and young scientists gathered in response to our call for participation. The symposium was focused on (I) the lymphocyte activation and repertoire selection, (II) the transcription factors in lymphopoiesis, and (III) the signal transduction in the lymphocyte activation.From the above activities and accomplishments, in conclusion, this Research Program is believed to be successfully completed and it is no doubt that member investigators have obtained fruitful results from their respective collaboration supported by this Program. Less