Studies on the regulation of gene expression in lymphoid cells.

点击翻译按钮获取中文摘要

This project has been accomplished for the purpose of promoting collaborative studies between Japanese and American immunologists and molecular biologists. During the term of this project (1) two of the Japanese member investigators were sent to the United States of America and (2) the symposium on the mechanisms of immune regulation and tolerance was held in Fukuoka, Japan.(1) Sending of Japanese member scientists to the U.S.A. for collaboration.(i) Dr.T.Kishimoto was sent to the U.S.A. from November 29 to December 5, 1992. He visited NIH in Bethesda for having discussion with Dr.W.E.Paul and Dr.T.Waldmann on the signaling mechanisms through cytokine receptors and on the aberrant cytokine gene expression in immunological disorders. He also made a visit to UCLA in Los Angeles for arranging a collaborative project with Dr.O.Martinez-Maza regarding molecular biological dissection of the pathology of AIDS.(ii) Dr.S.-I.Nishikawa was sent to Taos, New Mexico in the U.S.A. from January 1 to … More February 8, 1993 for attending the symposium on the molecular aspect of B lymphocyte differentiation. In this symposium, he discussed with Dr.P.Kincade and Dr.D.Baltimore (members of this Monbusho Research Program) as well as their colleagues. Based on Dr.Nishikawa's presentation suggesting involvement of p53 proto-oncogene product in the cell cycle arrest of pre-B cells at the V-D-J recombination, he discussed with some American researchers and has successfully arranged a collaborative study in this regard. The preparation of anti-IL-7 receptor inhibitory antibody was also reported there, and Dr.Nishikawa has made a contact with American scientists to start collaboration on B cell differentiation by the use of this antibody.(2) The symposium on the mechanisms of immune regulation and tolerance was held from March 2 to March 3, 1993 in Fukuoka. In this symposium, 17 presentations were made by Japanese and American top-ranking scientists in this field. The participants intensively made discussion based on their very recent knowledge throughout the symposium. In addition to the speakers, over a hundred Japanese leading immunologists and young scientists gathered in response to our call for participation. The symposium was focused on (I) the lymphocyte activation and repertoire selection, (II) the transcription factors in lymphopoiesis, and (III) the signal transduction in the lymphocyte activation.From the above activities and accomplishments, in conclusion, this Research Program is believed to be successfully completed and it is no doubt that member investigators have obtained fruitful results from their respective collaboration supported by this Program. Less